急性播散性脑脊髓炎的诊断考量及与髓鞘少突胶质细胞糖蛋白（MOG）抗体相关情况
Diagnostic Considerations in Acute Disseminated Encephalomyelitis and the Interface with MOG Antibody.
作者信息
Santoro Jonathan D, Chitnis Tanuja
机构信息
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States.
Department of Neurology, Harvard Medical School, Boston, Massachusetts, United States.
出版信息
Neuropediatrics. 2019 Oct;50(5):273-279. doi: 10.1055/s-0039-1693152. Epub 2019 Jul 24.
Abstract
Acute disseminated encephalomyelitis (ADEM) is a common yet clinically heterogenous syndrome characterized by encephalopathy, focal neurologic findings, and abnormal neuroimaging. Differentiating ADEM from other demyelinating disorders of childhood can be difficult and appropriate interpretation of the historical, clinical, and neurodiagnostic components of a patient's presentation is critical. Myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases are a recently recognized set of disorders, which include ADEM presentations, among other phenotypes. This review article discusses the clinical diagnosis, differential diagnosis, interpretation of data, and treatment/prognosis of this unique syndrome with distinctive review of the spectrum of MOG antibodies.
摘要
急性播散性脑脊髓炎（ADEM）是一种常见但临床异质性的综合征，其特征为脑病、局灶性神经学表现和神经影像学异常。将ADEM与儿童期其他脱髓鞘疾病区分开来可能具有挑战性，对患者临床表现的病史、临床和神经诊断要素进行恰当解读至关重要。髓鞘少突胶质细胞糖蛋白（MOG）抗体相关疾病是一组最近才被认识的疾病，其中包括ADEM表现及其他表型。本文综述讨论了这一独特综合征的临床诊断、鉴别诊断、数据解读以及治疗/预后，并对MOG抗体谱进行了特别综述。
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本文引用的文献
1
Early predictors of epilepsy and subsequent relapse in children with acute disseminated encephalomyelitis.
Mult Scler. 2020 Mar;26(3):333-342. doi: 10.1177/1352458518823486. Epub 2019 Feb 7.
2
Neurological update: MOG antibody disease.
J Neurol. 2019 May;266(5):1280-1286. doi: 10.1007/s00415-018-9122-2. Epub 2018 Dec 19.
3
Myelin oligodendrocyte glycoprotein antibodies in neurological disease.
Nat Rev Neurol. 2019 Feb;15(2):89-102. doi: 10.1038/s41582-018-0112-x.
4
Temporal Trends of Pediatric Hospitalizations with Acute Disseminated Encephalomyelitis in the United States: An Analysis from 2006 to 2014 using National Inpatient Sample.
J Pediatr. 2019 Mar;206:26-32.e1. doi: 10.1016/j.jpeds.2018.10.044. Epub 2018 Dec 6.
5
Factors Related to Long Term Motor, Behavioral, and Scholastic Outcome in Children with Acute Disseminated Encephalomyelitis.
Pediatr Neurol. 2018 Dec;89:49-57. doi: 10.1016/j.pediatrneurol.2018.08.015. Epub 2018 Sep 21.
6
Retrospective analysis of children with myelin oligodendrocyte glycoprotein antibody-related disorders.
Mult Scler Relat Disord. 2018 Nov;26:1-7. doi: 10.1016/j.msard.2018.07.022. Epub 2018 Sep 10.
7
A case of anti-MOG antibody-positive unilaterally dominant meningoencephalitis followed by longitudinally extensive transverse myelitis.
Mult Scler Relat Disord. 2018 Oct;25:128-130. doi: 10.1016/j.msard.2018.07.028. Epub 2018 Jul 26.
8
Association of MOG-IgG Serostatus With Relapse After Acute Disseminated Encephalomyelitis and Proposed Diagnostic Criteria for MOG-IgG-Associated Disorders.
JAMA Neurol. 2018 Nov 1;75(11):1355-1363. doi: 10.1001/jamaneurol.2018.1814.
9
MOG encephalomyelitis: international recommendations on diagnosis and antibody testing.
J Neuroinflammation. 2018 May 3;15(1):134. doi: 10.1186/s12974-018-1144-2.
10
Disease Course and Treatment Responses in Children With Relapsing Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.
JAMA Neurol. 2018 Apr 1;75(4):478-487. doi: 10.1001/jamaneurol.2017.4601.
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