半胱氨酸组织蛋白酶在癌症进展和耐药性中的作用。
The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance.
机构信息
Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Institute for Urology and Reproductive Health, Sechenov University, 119992 Moscow, Russia.
出版信息
Int J Mol Sci. 2019 Jul 23;20(14):3602. doi: 10.3390/ijms20143602.
Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associated with highly aggressive tumor phenotypes, their mechanistic role in cancer progression is still to be determined to develop new therapeutic strategies. In this review, we highlight the literature related to the role of the cysteine cathepsins in cancer biology, with particular emphasis on their input into tumor biology.
半胱氨酸组织蛋白酶属于木瓜蛋白酶家族的溶酶体酶。它们的表达在各种肿瘤中失调，大量数据证明它们参与了癌症的进展、血管生成、转移以及耐药性的产生。然而，虽然它们的过度表达通常与高度侵袭性的肿瘤表型相关，但它们在癌症进展中的机制作用仍有待确定，以开发新的治疗策略。在这篇综述中，我们强调了与半胱氨酸组织蛋白酶在癌症生物学中的作用相关的文献，特别强调了它们对肿瘤生物学的贡献。
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