Karaer Isil, Tuncay Gorkem
Ministry of Health, ENT Clinic, Malatya Training and Research Hospital, Malatya, Turkey.
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Inonu University Medical School of Medicine, Malatya, Turkey.
J Obstet Gynaecol. 2020 Feb;40(2):247-251. doi: 10.1080/01443615.2019.1621815. Epub 2019 Jul 25.
The aim of this study was to test whether hearing function is impaired in women with premature ovarian failure. Thirty (30) women with premature ovarian failure (POF), 30 women in menopause and 30 healthy controls were recruited in this study. Pure tone audiometric (PTA), transiently evoked otoacoustic emissions (TEOAEs) and distortion product otoacoustic emissions (DPOAEs) of the study participants were analysed. At PTA, 6 and 8 kHz were lower in menopause group compared with both women with POF and controls. At TEOAE 3 and 4 kHz and at DPOAE 1, 2, 4 and 6 kHz were lower in menopause group compared with the controls. At DPOAE 6 kHz was lower in the POF group compared with the controls. Women with POF comparing to menopause group at TEOAE 3, 4 kHz and at DPOAE 4 and 6 kHz were lower in the menopause group. Inner ear function of both women in menopause and women with POF was declined compared to the healthy controls. Clinically, evaluation of hearing status may be considered in women with POF.Impact statement Premature ovarian failure (POF) affects 1%-2% of women, and it adversely effects on health status (such as cardiovascular, psychological and cognitive disorders). Previous studies suggested that a lack of oestrogen might play a role in hearing disorders in women. However, we do not know POF's adversely effect on cochlea and hearing.: The present study demonstrates that lower serum oestrogen has a negative effect hearing in women with POF at DPOAE 6 kHz. The women with POF must be evaluated for hearing status.
本研究的目的是测试卵巢早衰女性的听力功能是否受损。本研究招募了30名卵巢早衰（POF）女性、30名绝经女性和30名健康对照者。分析了研究参与者的纯音听力测定（PTA）、瞬态诱发耳声发射（TEOAEs）和畸变产物耳声发射（DPOAEs）。在PTA方面，绝经组6kHz和8kHz的数值低于POF女性组和对照组。在TEOAEs方面，绝经组3kHz和4kHz以及在DPOAEs方面，绝经组1kHz、2kHz、4kHz和6kHz的数值低于对照组。在DPOAEs方面，POF组6kHz的数值低于对照组。在TEOAEs方面，POF女性组3kHz、4kHz以及在DPOAEs方面，POF女性组4kHz和6kHz的数值低于绝经组。与健康对照组相比，绝经女性和POF女性的内耳功能均有所下降。临床上，对于POF女性可考虑评估其听力状况。影响声明：卵巢早衰（POF）影响1%-2%的女性，并对健康状况产生不利影响（如心血管、心理和认知障碍）。先前的研究表明，雌激素缺乏可能在女性听力障碍中起作用。然而，我们尚不清楚POF对耳蜗和听力的不利影响。本研究表明，血清雌激素水平较低对POF女性在DPOAEs 6kHz时的听力有负面影响。必须对POF女性的听力状况进行评估。
