Laboratory of Molecular Medicine, Department of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Mansa Road, Bathinda 151001, Punjab, India.
Centre for Systems Biology and Bioinformatics, Panjab University, Sector-25, Chandigarh 160014, India.
Curr Mol Med. 2019;19(9):621-631. doi: 10.2174/1566524019666190723165357.
MicroRNAs [miRNAs] are short, non-coding, single stranded RNA molecules regulating gene expression of their targets at the posttranscriptional level by either degrading mRNA or by inhibiting translation. Previously, miRNAs have been reported to be present inside the mitochondria and these miRNAs have been termed as mito-miRs. Origin of these mito-miRs may either be from mitochondrial genome or import from nucleus. The second class of mito-miRs makes it important to unravel the involvement of miRNAs in crosstalk between nucleus and mitochondria. Since miRNAs are involved in various physiological processes, their deregulation is often associated with disease progression, including cancer. The current review focuses on the involvement of miRNAs in different mitochondrial mediated processes. It also highlights the importance of exploring the interaction of miRNAs with mitochondrial genome, which may lead to the development of small regulatory RNA based therapeutic options.
微小 RNA（miRNAs）是短的、非编码的、单链 RNA 分子，通过降解 mRNA 或抑制翻译，在转录后水平调节靶基因的表达。先前已有报道称，miRNAs 存在于线粒体内部，这些 miRNAs 被称为 mito-miRs。这些 mito-miRs 的来源可能来自线粒体基因组或从核输入。第二类 mito-miRs 使得揭示 miRNA 参与核与线粒体之间串扰的重要性凸显出来。由于 miRNAs 参与各种生理过程，其失调通常与疾病进展有关，包括癌症。本综述重点介绍了 miRNAs 在不同的线粒体介导过程中的作用。它还强调了探索 miRNA 与线粒体基因组相互作用的重要性，这可能导致基于小调节 RNA 的治疗选择的发展。
