Department of Psychology, University of Sheffield, Cathedral Court, 1 Vicar Lane, Sheffield S1 2LT, UK.
Human Appetite Research Unit, Appetite Control and Energy Balance Group, School of Psychology, University of Leeds, Leeds LS2 9JT, UK.
Br J Nutr. 2019 Oct 28;122(8):951-959. doi: 10.1017/S000711451900179X.
This trial compared weight loss outcomes over 14 weeks in women showing low- or high-satiety responsiveness (low- or high-satiety phenotype (LSP, HSP)) measured by a standardised protocol. Food preferences and energy intake (EI) after low and high energy-density (LED, HED) meals were also assessed. Ninety-six women (n 52 analysed; 41·24 (SD 12·54) years; 34·02 (sd 3·58) kg/m2) engaged in one of two weight loss programmes underwent LED and HED laboratory test days during weeks 3 and 12. Preferences for LED and HED food (Leeds Food Preference Questionnaire) and ad libitum evening meal and snack EI were assessed in response to equienergetic LED and HED breakfasts and lunches. Weekly questionnaires assessed control over eating and ease of adherence to the programme. Satiety quotients based on subjective fullness ratings post LED and HED breakfasts determined LSP (n 26) and HSP (n 26) by tertile splits. Results showed that the LSP lost less weight and had smaller reductions in waist circumference compared with HSP. The LSP showed greater preferences for HED foods, and under HED conditions, consumed more snacks (kJ) compared with HSP. Snack EI did not differ under LED conditions. LSP reported less control over eating and reported more difficulty with programme adherence. In conclusion, low-satiety responsiveness is detrimental for weight loss. LED meals can improve self-regulation of EI in the LSP, which may be beneficial for longer-term weight control.
本试验通过标准方案比较了低饱腹感反应（低饱腹感表型（LSP）或高饱腹感表型（HSP））女性在 14 周内的减肥效果。还评估了低和高能量密度（LED、HED）膳食后食物偏好和能量摄入（EI）。96 名女性（n=52 分析；41.24（SD 12.54）岁；34.02（sd 3.58）kg/m2）参与了两种减肥方案中的一种，在第 3 周和第 12 周进行了 LED 和 HED 实验室测试日。在早餐和午餐提供等能量的 LED 和 HED 后，通过 Leeds 食物偏好问卷评估对 LED 和 HED 食物的偏好以及随意的晚餐和零食 EI。每周的问卷评估对饮食的控制和对方案的依从性。根据 LED 和 HED 早餐后主观饱腹感评分得出的饱腹感指数确定 LSP（n=26）和 HSP（n=26），通过三分位数划分。结果表明，与 HSP 相比，LSP 体重减轻较少，腰围减少较小。LSP 对 HED 食物的偏好更大，在 HED 条件下，与 HSP 相比，消耗更多的零食（kJ）。在 LED 条件下，零食 EI 没有差异。LSP 报告对饮食的控制较少，并且报告在方案依从性方面存在更多困难。总之，低饱腹感反应不利于减肥。LED 膳食可以改善 LSP 对 EI 的自我调节，这可能对长期体重控制有益。
