通过持续杏仁核内注入6-羟基多巴胺证明儿茶酚胺在杏仁核点燃发展中的双功能作用。

Bifunctional roles of catecholamines in the development of amygdala kindling demonstrated by continuous intra-amygdala infusion of 6-hydroxydopamine.

作者信息

Uemura S, Kimura H, Kashiba A, Kumashiro H, Wada J A

机构信息

Department of Anatomy, Shiga University of Medical Science, Otsu, Japan.

出版信息

Brain Res. 1988 May 10;448(1):162-6. doi: 10.1016/0006-8993(88)91113-4.

DOI:10.1016/0006-8993(88)91113-4

PMID:3134112

Abstract

Details of seizure stage progression in amygdala kindling were studied in the cat under local denervation of catecholamine input to the amygdala. A chemitrode was used for both electrical stimulation and continuous infusion of 6-hydroxydopamine. The extent of denervation was confirmed by fluorescence histochemistry. The result has indicated that catecholamine afferents to the amygdala exert biphasic roles in normal kindling: inhibitory in the early local and late generalized seizure stages, whereas facilitatory in the intermediate stage.

摘要

在猫身上，通过对杏仁核的儿茶酚胺输入进行局部去神经支配，研究了杏仁核点燃中癫痫发作阶段进展的细节。使用化学电极进行电刺激和6-羟基多巴胺的持续输注。通过荧光组织化学确认去神经支配的程度。结果表明，杏仁核的儿茶酚胺传入在正常点燃中发挥双相作用：在早期局部和晚期全身性癫痫发作阶段起抑制作用，而在中间阶段起促进作用。