Michelson H B, Buterbaugh G G
Exp Neurol. 1985 Dec;90(3):588-93. doi: 10.1016/0014-4886(85)90156-6.
The role of catecholamines in mediating the acquisition of amygdala-kindled seizures was investigated in juvenile rats administered intracisternal injections of 6-hydroxydopamine (6-OHDA) on postnatal days 1 and 2. Amygdala kindling was initiated on day 28, using stimulations delivered each hour through two consecutive stage V seizures. The 6-OHDA treatment resulted in a 53% increase in the overall rate of kindling in juvenile rats. This acceleration was confined primarily to the early phases of kindling in that the 6-OHDA-treated rats skipped the early kindling stages, and the later stages of kindling were unaffected. These findings support evidence from adult rats that catecholamines play a role in initially limiting the spread of seizure activity during kindled seizure acquisition; however, when the seizures have begun to generalize, the ability of catecholaminergic systems to inhibit seizure spread diminishes.
在出生后第1天和第2天经脑池内注射6-羟基多巴胺（6-OHDA）的幼鼠中，研究了儿茶酚胺在介导杏仁核点燃性癫痫发作获得过程中的作用。在第28天开始进行杏仁核点燃，通过连续两次V期癫痫发作每小时给予刺激。6-OHDA处理使幼鼠的总体点燃率提高了53%。这种加速主要局限于点燃的早期阶段，因为经6-OHDA处理的大鼠跳过了早期点燃阶段，而点燃的后期阶段未受影响。这些发现支持了成年大鼠的证据，即儿茶酚胺在点燃性癫痫发作获得过程中最初限制癫痫活动扩散方面发挥作用；然而，当癫痫发作开始泛化时，儿茶酚胺能系统抑制癫痫扩散的能力会减弱。
