Sugiura Mieko, Shibata Koichi, Saito Satoshi, Nishimura Yoshiko, Takahashi Koichi, Sakura Hiroshi
Department of Internal Medicine, Tokyo Women's Medical University Medical Center East.
Department of Neurosurgery, Sanno Hospital.
Rinsho Shinkeigaku. 2019 Aug 29;59(8):530-535. doi: 10.5692/clinicalneurol.cn-001298. Epub 2019 Jul 23.
A 41-year-old woman experienced back pain upon waking up. Immediately afterward, she experienced a continual orthostatic headache. Thereafter, right ear fullness and dizziness also occurred. One month later, she became aware of repeated numbness that started in the right hand and spread to the right half of the body and lower limbs and continued for repeated periods of approximately 20-30 min. Neurological examination revealed no abnormal findings except for orthostatic headache. Electroencephalography showed no epileptic discharge. Head MRI revealed left convexal subarachnoid hemorrhage (cSAH) restricted to the prefrontal sulcus, left frontal cerebral venous thrombosis, diffuse dural thickening with gadolinium enhancement, and subdural hematoma in the posterior cranial fossa. Spinal MRI revealed epidural fluid accumulation around the thoracic spine. CT myelography revealed cerebrospinal fluid leakages at the cervical, thoracic, and lumbar vertebrae levels. The patient was diagnosed with spontaneous intracranial hypotension (SIH), which was treated effectively with a blood patch. In this case, cSAH may have resulted from rupturing of the vessel wall as a result of cortical venous thrombosis induced by SIH. The repeated transient neurologic symptoms suggesting migraine aura may have originated from cSAH, which in turn led to cortical spreading depression. The diagnosis and management of SIH can be often difficult; therefore, repeated migraine-aura-like symptoms are a critical sign of complication with cSAH and cortical venous thrombosis.
一名41岁女性醒来后出现背痛。随后,她持续出现体位性头痛。此后,还出现了右耳胀满感和头晕。1个月后,她开始意识到右手反复出现麻木,并蔓延至身体右半侧及下肢,每次持续约20 - 30分钟。神经系统检查除体位性头痛外无异常发现。脑电图显示无癫痫放电。头部MRI显示局限于额前沟的左侧凸面蛛网膜下腔出血(cSAH)、左侧额叶脑静脉血栓形成、钆增强的硬脑膜弥漫性增厚以及后颅窝硬膜下血肿。脊柱MRI显示胸椎周围硬膜外积液。CT脊髓造影显示颈椎、胸椎和腰椎水平有脑脊液漏。该患者被诊断为自发性颅内低压(SIH),通过血液填充疗法得到有效治疗。在这种情况下,cSAH可能是由SIH诱发的皮质静脉血栓形成导致血管壁破裂所致。提示偏头痛先兆的反复短暂性神经症状可能源于cSAH,进而导致皮质扩散性抑制。SIH的诊断和治疗通常可能具有挑战性;因此,反复出现类似偏头痛先兆的症状是并发cSAH和皮质静脉血栓形成的关键体征。