Møller-Petersen J, Ladefoged J
Department of Clinical Chemistry, Aalborg Hospital, Denmark.
Clin Chim Acta. 1988 Jun 15;174(3):241-54. doi: 10.1016/0009-8981(88)90050-2.
The renal handling of cathodic trypsin-like immunoreactivity (TLI) was examined in 60 healthy persons (group I), 59 patients with proteinuria (group II), 7 healthy men receiving intravenous lysine to partially inhibit renal tubular protein reabsorption (group III) and 20 patients who underwent diagnostic renal vein catheterization (group IV). The urinary TLI concentration and TLI ratio (TLI clearance divided with creatinine clearance) were higher in group II than group I (p less than 0.001, Mann-Whitney test). In group II negative correlations were present between serum TLI and creatinine clearance (Spearman's rho = -0.84, p less than 0.001) and between TLI ratio and creatinine clearance (rho = -0.76, p less than 0.001). In group III the renal TLI clearance was undetectable before lysine but increased to a maximal median value of 4.00 ml/min per 1.73 m2 (range: 2.44-9.25 ml/min per 1.73 m2) after lysine. In group IV, the renal arterio-venous extraction of TLI was correlated to inulin extraction (rho = 0.85, p less than 0.001). The glomerular filtrability (the ratio between TLI and inulin extractions) was median 0.53 (range: 0.13-0.94). In conclusion, TLI has a high glomerular filtration and an almost complete tubular reabsorption and catabolism (with normal kidney function).
在60名健康人（第一组）、59名蛋白尿患者（第二组）、7名接受静脉赖氨酸输注以部分抑制肾小管蛋白重吸收的健康男性（第三组）以及20名接受诊断性肾静脉插管的患者（第四组）中，研究了肾脏对阴极胰蛋白酶样免疫反应性（TLI）的处理情况。第二组的尿TLI浓度和TLI比率（TLI清除率除以肌酐清除率）高于第一组（p<0.001，Mann-Whitney检验）。在第二组中，血清TLI与肌酐清除率之间存在负相关（Spearman秩相关系数rho=-0.84，p<0.001），TLI比率与肌酐清除率之间也存在负相关（rho=-0.76，p<0.001）。在第三组中，赖氨酸输注前肾脏TLI清除率无法检测到，但输注后增加至最大中位数4.00 ml/min per 1.73 m2（范围：2.44 - 9.25 ml/min per 1.73 m2）。在第四组中，TLI的肾动静脉提取率与菊粉提取率相关（rho = 0.85，p<0.001）。肾小球滤过性（TLI与菊粉提取率之比）中位数为0.53（范围：0.13 - 0.94）。总之，在肾功能正常的情况下，TLI具有高肾小球滤过率以及几乎完全的肾小管重吸收和分解代谢。
