Møller-Petersen J, Pedersen S
Clin Chim Acta. 1982 Sep 1;124(1):31-7. doi: 10.1016/0009-8981(82)90316-3.
Radioimmunologically determined cathodic trypsin-like immunoreactivity (TLI) in serum was positively correlated with age (Spearman's rho = 0.40, p less than 0.001) and negatively correlated with estimated creatinine clearance (Spearman's rho = -0.31, p less than 0.01) in healthy adults (37 women, 27 men) under standard conditions. Women had higher TLI concentrations than men (median value 358 micrograms trypsin standard/l compared with 283 micrograms trypsin standard/l, p less than 0.02). A clinically significant uptake of cathodic trypsin from the intestine to the blood is not likely because no change was found in serum concentrations of TLI and the two major protease inhibitors (alpha 1-antitrypsin and alpha 2-macroglobulin) one hour after a standard meal. No diurnal variation of TLI in serum was found in a group of 12 healthy subjects. The results indicate that due consideration must be given to sex, age and renal function of the persons used in reference groups for TLI determination.
在标准条件下，对健康成年人（37名女性，27名男性）进行研究，结果显示血清中通过放射免疫法测定的阴极类胰蛋白酶免疫反应性（TLI）与年龄呈正相关（斯皮尔曼等级相关系数rho = 0.40，p < 0.001），与估计的肌酐清除率呈负相关（斯皮尔曼等级相关系数rho = -0.31，p < 0.01）。女性的TLI浓度高于男性（中位数分别为358微克胰蛋白酶标准/升和283微克胰蛋白酶标准/升，p < 0.02）。由于在标准餐后一小时，血清中TLI以及两种主要蛋白酶抑制剂（α1-抗胰蛋白酶和α2-巨球蛋白）的浓度未发现变化，所以不太可能存在从肠道到血液的具有临床意义的阴极类胰蛋白酶摄取。在一组12名健康受试者中未发现血清TLI的昼夜变化。结果表明，在确定TLI的参考组中所使用的人员的性别、年龄和肾功能必须予以充分考虑。
