基于目标催化发夹组装与距离可控的多重信号放大偶联的 miRNA-21 分析的超灵敏光电化学生物传感器
Ultrasensitive photoelectrochemical biosensor for MiRNA-21 assay based on target-catalyzed hairpin assembly coupled with distance-controllable multiple signal amplification.
机构信息
Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China.
出版信息
Chem Commun (Camb). 2019 Aug 21;55(65):9622-9625. doi: 10.1039/c9cc04987h. Epub 2019 Jul 25.
PMID:31342017
Abstract
Here, with the target-catalyzed hairpin assembly generated dsDNA (HP1-HP2) to synchronously control the departure of quencher ferrocene and approach of sensitizer methylene blue, a distance-controllable multiple signal amplification based photoelectrochemical biosensor was proposed for MiRNA-21 assay.
摘要
在这里，利用目标催化发夹组装生成的 dsDNA（HP1-HP2）来同步控制猝灭剂二茂铁的离去和敏化剂亚甲基蓝的接近，提出了一种基于距离可控的多重信号放大光电化学生物传感器用于检测 miRNA-21。
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