Department of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University, Amman, 11931, Jordan.
Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, The University of Jordan, Amman, 11942, Jordan.
AAPS PharmSciTech. 2019 Jul 24;20(7):265. doi: 10.1208/s12249-019-1477-x.
Here we investigated the disintegration action of the natural superdisintegrant soy polysaccharide (SP) and benchmarked it against sodium starch glycolate (SSG) and crospovidone (XPVP). Kinetics and mechanism of disintegration of various tablet formulations were monitored using a USB microscope connected to a computer, followed by image analysis. SP acts mainly by a swelling mechanism and it is most effective at concentrations of 4-8%. Its disintegration action is comparable with that of SSG and XPVP, in most cases. However, SP underperforms compared with these superdisintegrants, in extremely hard tablets containing a hydrophobic component. Moreover, it is more negatively affected by the concentration of magnesium stearate than SSG and XPVP. The disintegration action of SP is not affected by pH and ionic strength of the medium, but it is compromised by the presence of ethanol. This indicates that the concomitant administration of alcoholic beverages might hamper the disintegration of SP-containing tablets. Overall, SP is a promising tablet disintegrant for pharmaceutical and nutraceutical products.
在这里，我们研究了天然超级崩解剂大豆多糖（SP）的崩解作用，并将其与交联羧甲淀粉钠（SSG）和交聚维酮（XPVP）进行了基准比较。使用连接到计算机的 USB 显微镜监测各种片剂配方的崩解动力学和机制，然后进行图像分析。SP 主要通过溶胀机制起作用，在 4-8%的浓度下效果最佳。在大多数情况下，它的崩解作用与 SSG 和 XPVP 相当。然而，在含有疏水成分的极硬片剂中，SP 的性能逊于这些超级崩解剂。此外，它比 SSG 和 XPVP 更容易受到硬脂酸镁浓度的影响。SP 的崩解作用不受介质 pH 值和离子强度的影响，但会受到乙醇的影响。这表明同时服用含酒精的饮料可能会阻碍含有 SP 的片剂的崩解。总的来说，SP 是一种有前途的医药和营养保健品片剂崩解剂。
