聚己内酯、聚（ε-己内酯-共聚-L-乳酸）和聚 L-乳酸作为鼠组织工程血管移植物支架密封聚合物的降解和评价。
Degradation and evaluation of polycaprolactone, poly(ε-caprolactone-co-L-lactide), and poly-L-lactic acid as scaffold sealant polymers for murine tissue-engineered vascular grafts.
机构信息
Center for Regenerative Medicine at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
出版信息
Regen Med. 2019 Jul;14(7):627-637. doi: 10.2217/rme-2018-0069. Epub 2019 Jul 25.
Abstract
This study evaluates scaffold degradation and neotissue formation as a function of sealant polymer composition in tissue-engineered vascular grafts (TEVGs). Scaffolds fabricated from polyglycolic acid core and sealant composed of polycaprolactone (PCL), poly-L-lactic-acid (PLLA) or 50:50 copolymer poly(ε-caprolactone-co-L-lactide) (PCLA) were analyzed using accelerated degradation and scanning electron microscopy, and following implantation in a murine inferior vena cava interposition model. and characterization revealed statistically greater degradation of PCLA compared with both PCL and PLLA scaffolds, with similar neotissue formation across all groups. The wall thickness of PLLA TEVGs was statistically greater than PCL TEVGs at 2 weeks postimplant. Results of this study can be used to inform the rational design of future TEVGs.
摘要
本研究评估了支架降解和新组织形成作为组织工程血管移植物（TEVG）中密封聚合物组成的函数。 采用聚乙二醇酸芯和由聚己内酯（PCL）、聚 L-乳酸（PLLA）或 50:50 共聚物聚（ε-己内酯-co-L-乳酸）（PCLA）组成的密封剂制造的支架，通过加速降解和扫描电子显微镜进行分析，并在小鼠下腔静脉间置模型中进行植入后的分析。 结果表明，与 PCL 和 PLLA 支架相比，PCLA 支架的降解程度明显更大，而所有组的新组织形成情况相似。植入后 2 周时，PLLA TEVG 的壁厚明显大于 PCL TEVG。 本研究的结果可用于为未来的 TEVG 的合理设计提供信息。
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