Huckins Gail L, Eshar David, Schwartz Diana, Morton Mark, Herrin Brian H, Cerezo Argine, Yabsley Michael J, Schneider Sarah M
Departments of Clinical Sciences (Huckins, Eshar), College of Veterinary of Medicine, Kansas State University, Manhattan, KS.
Diagnostic Medicine/Pathobiology (Schwartz, Morton, Herrin, Cerezo, Schneider), College of Veterinary of Medicine, Kansas State University, Manhattan, KS.
J Vet Diagn Invest. 2019 Sep;31(5):752-755. doi: 10.1177/1040638719865926. Epub 2019 Jul 25.
A 9-y-old, zoo-housed, male red panda () became progressively lethargic and inappetent over a 1-wk period. Physical examination was unremarkable. A complete blood count showed mild normocytic, normochromic, non-regenerative anemia with the presence of trypomastigote organisms, consistent with a sp. The organism was confirmed later as lineage TcI via PCR and genome sequencing. The panda was initially treated supportively; however, its clinical status within 24 h from presentation deteriorated, and euthanasia was elected. Autopsy showed severe systemic infection with the presence of amastigotes in the heart, brain, peripheral nerves, skeletal muscles, tongue, liver, and testes. We used genome sequencing and serology in identifying the agent.
一只9岁的圈养雄性小熊猫在1周内逐渐变得嗜睡且食欲不振。体格检查无异常。全血细胞计数显示轻度正细胞、正色素性非再生性贫血，并存在锥鞭毛体生物，与锥虫属相符。该生物后来通过PCR和基因组测序被确认为锥虫属TcI谱系。这只小熊猫最初接受了支持性治疗；然而，从就诊起24小时内其临床状况恶化，于是选择了安乐死。尸检显示严重的全身性锥虫感染，心脏、大脑、外周神经、骨骼肌、舌头、肝脏和睾丸中存在无鞭毛体。我们使用基因组测序和血清学来鉴定病原体。
