Pan Shulei, Wu Binqiang, Hu Jinjin, Xu Ruigang, Jiang Min, Zeng Xiaofei, Zhong Guofu
College of Materials, Chemistry and Chemical Engineering , Hangzhou Normal University , Hangzhou 311121 , China.
J Org Chem. 2019 Aug 16;84(16):10111-10119. doi: 10.1021/acs.joc.9b01313. Epub 2019 Aug 7.
An efficient tetrakis(triphenylphosphine)palladium- and Brønsted acid catalyzed allylic substitution reaction of benzothiazolylacetamide with allylic alcohols in water has been developed, and the corresponding allylated products were afforded in good to excellent (up to 99%) yields with high regioselectivities. This straightforward protocol exhibits good functional group tolerance and scalability.
已开发出一种高效的四（三苯基膦）钯和布朗斯特酸催化的苯并噻唑基乙酰胺与烯丙醇在水中的烯丙基取代反应，相应的烯丙基化产物以良好至优异（高达99%）的产率和高区域选择性得到。这种直接的方法具有良好的官能团耐受性和可扩展性。
