Zoology Department - Faculty of Science, Cairo University, Giza, 12613, Egypt.
Zoology Department - Faculty of Science, Cairo University.
Nat Prod Res. 2021 Jun;35(11):1928-1932. doi: 10.1080/14786419.2019.1644633. Epub 2019 Jul 25.
The present investigation attempted study the potential use of the saponin (HaS) against Ehrlich Ascites Carcinoma (EAC) tumor model in female Swiss albino mice. The HPLC studies of the extracted saponin showed the peak at retention time 5.19 min. was is matched with the standard saponin with total amount 34.87%. Significant improvements were detected in the tumor markers, complete blood count, antioxidant system, liver function and kidney function of HaS-treated mice. The present study demonstrated that HaS is a potent natural product that has promising antineoplastic efficacy.
本研究试图探讨皂素（HaS）在雌性瑞士白化病小鼠艾氏腹水癌（EAC）肿瘤模型中的潜在应用。提取的皂素的 HPLC 研究表明，保留时间为 5.19 分钟的峰与总含量为 34.87%的标准皂素相匹配。HaS 处理组小鼠的肿瘤标志物、全血细胞计数、抗氧化系统、肝功能和肾功能均有显著改善。本研究表明，HaS 是一种有效的天然产物，具有有前途的抗肿瘤功效。
