School of Sport and Wellbeing, Institute of Coaching and Performance, University of Central Lancashire, Preston, United Kingdom.
Prenetics DNAFit Research Center, London, United Kingdom.
J Strength Cond Res. 2019 Sep;33(9):2344-2351. doi: 10.1519/JSC.0000000000003259.
Pickering, C, Suraci, B, Semenova, EA, Boulygina, EA, Kostryukova, ES, Kulemin, NA, Borisov, OV, Khabibova, SA, Larin, AK, Pavlenko, AV, Lyubaeva, EV, Popov, DV, Lysenko, EA, Vepkhvadze, TF, Lednev, EM, Leońska-Duniec, A, Pająk, B, Chycki, J, Moska, W, Lulińska-Kuklik, E, Dornowski, M, Maszczyk, A, Bradley, B, Kana-ah, A, Cięszczyk, P, Generozov, EV, and Ahmetov, II. A genome-wide association study of sprint performance in elite youth football players. J Strength Cond Res 33(9): 2344-2351, 2019-Sprint speed is an important component of football performance, with teams often placing a high value on sprint and acceleration ability. The aim of this study was to undertake the first genome-wide association study to identify genetic variants associated with sprint test performance in elite youth football players and to further validate the obtained results in additional studies. Using micro-array data (600 K-1.14 M single nucleotide polymorphisms [SNPs]) of 1,206 subjects, we identified 12 SNPs with suggestive significance after passing replication criteria. The polymorphism rs55743914 located in the PTPRK gene was found as the most significant for 5-m sprint test (p = 7.7 × 10). Seven of the discovered SNPs were also associated with sprint test performance in a cohort of 126 Polish women, and 4 were associated with power athlete status in a cohort of 399 elite Russian athletes. Six SNPs were associated with muscle fiber type in a cohort of 96 Russian subjects. We also examined genotype distributions and possible associations for 16 SNPs previously linked with sprint performance. Four SNPs (AGT rs699, HSD17B14 rs7247312, IGF2 rs680, and IL6 rs1800795) were associated with sprint test performance in this cohort. In addition, the G alleles of 2 SNPs in ADRB2 (rs1042713 & rs1042714) were significantly over-represented in these players compared with British and European controls. These results suggest that there is a genetic influence on sprint test performance in footballers, and identifies some of the genetic variants that help explain this influence.
皮克林、C、苏拉奇、B、塞米诺娃、E.A.、布柳金娜、E.A.、科斯特鲁科娃、E.S.、库里明、N.A.、鲍里索夫、O.V.、哈比波娃、S.A.、拉林、A.K.、帕夫连科、A.V.、柳巴耶娃、E.V.、波波夫、D.V.、列先科、E.A.、韦普赫瓦德泽、T.F.、列德涅夫、E.M.、列奥尼什娜-敦涅茨、A.、帕伊亚克、B.、奇基、J.、莫斯卡、W.、卢利涅斯卡娅-库利克、E.、多诺夫斯基、M.、马什奇克、A.、布拉德利、B.、卡纳阿、A.、奇采克、P.、杰热佐夫、E.V.、阿赫梅托夫、II. 精英青年足球运动员短跑表现的全基因组关联研究。J 力量与调理研究 33(9):2344-2351,2019-短跑速度是足球表现的一个重要组成部分，球队通常非常重视短跑和加速能力。本研究的目的是进行首次全基因组关联研究，以确定与精英青年足球运动员短跑测试表现相关的遗传变异，并在进一步的研究中进一步验证获得的结果。使用 1206 名受试者的微阵列数据（600 K-1.14 M 单核苷酸多态性[SNP]），我们在通过复制标准后发现了 12 个具有暗示意义的 SNP。位于 PTPRK 基因中的多态性 rs55743914 被发现与 5 米冲刺测试（p=7.7×10）最显著相关。在波兰的 126 名女性队列中，发现了 7 个发现的 SNP 也与冲刺测试性能相关，在俄罗斯的 399 名精英运动员队列中，有 4 个与力量运动员身份相关。在 96 名俄罗斯受试者的队列中，有 6 个 SNP 与肌肉纤维类型相关。我们还检查了先前与短跑表现相关的 16 个 SNP 的基因型分布和可能的关联。在该队列中，四个 SNP（AGT rs699、HSD17B14 rs7247312、IGF2 rs680 和 IL6 rs1800795）与冲刺测试性能相关。此外，与英国和欧洲对照组相比，ADRB2 中的 2 个 SNP（rs1042713 和 rs1042714）的 G 等位基因在这些运动员中显著过量。这些结果表明，足球运动员的短跑测试表现存在遗传影响，并确定了一些有助于解释这种影响的遗传变异。
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