Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
J Strength Cond Res. 2022 Jul 1;36(7):1884-1889. doi: 10.1519/JSC.0000000000003756. Epub 2020 Dec 9.
Guilherme, JPLF, Semenova, EA, Borisov, OV, Kostryukova, ES, Vepkhvadze, TF, Lysenko, EA, Andryushchenko, ON, Andryushchenko, LB, Lednev, EM, Larin, AK, Bondareva, EA, Generozov, EV, and Ahmetov, II. The BDNF-increasing allele is associated with increased proportion of fast-twitch muscle fibers, handgrip strength, and power athlete status. J Strength Cond Res 36(7): 1884-1889, 2022-The brain-derived neurotrophic factor (BDNF) is involved in neurogenesis and formation of regenerated myofibers following injury or damage. A recent study suggested that the BDNF overexpression increases the proportion of fast-twitch muscle fibers, while the BDNF deletion promotes a fast-to-slow transition. The purpose of this study was to evaluate the association between the BDNF gene rs10501089 polymorphism (associated with blood BDNF levels), muscle fiber composition, and power athlete status. Muscle fiber composition was determined in 164 physically active individuals (113 men, 51 women). BDNF genotype and allele frequencies were compared between 508 Russian power athletes, 178 endurance athletes, and 190 controls. We found that carriers of the minor A-allele (the BDNF-increasing allele) had significantly higher percentage of fast-twitch muscle fibers than individuals homozygous for the G-allele (males: 64.3 [7.8] vs. 50.3 [15.8]%, p = 0.0015; all subjects: 64.1 ± 7.9 vs. 49.6 ± 14.7%, p = 0.0002). Furthermore, the A-allele was associated (p = 0.036) with greater handgrip strength in a sub-group of physically active subjects (n = 83) and over-represented in power athletes compared with controls (7.7 vs. 2.4%, p = 0.0001). The presence of the A-allele (i.e., AA+AG genotypes) rather than GG genotype increased the odds ratio of being a power athlete compared with controls (odds ratio [OR]: 3.43, p = 0.00071) or endurance athletes (OR: 2.36, p = 0.0081). In conclusion, the rs10501089 A-allele is associated with increased proportion of fast-twitch muscle fibers and greater handgrip strength, and these may explain, in part, the association between the AA/AG genotypes and power athlete status.
杰勒米，JPLF，塞米诺娃，EA，鲍里索夫，OV，科斯特鲁科娃，ES，韦普赫瓦泽，TF，列先科，EA，安德烈休琴科，ON，安德烈休琴科，LB，列林，AK，邦达列娃，EA，杰尼索夫，EV，和阿赫梅托夫，II。BDNF 增加的等位基因与快肌纤维比例增加、握力增强和力量型运动员状态有关。J 力量与调节研究 36(7)：1884-1889，2022-脑源性神经营养因子 (BDNF) 参与神经发生和损伤或损伤后再生肌纤维的形成。最近的一项研究表明，BDNF 的过表达增加了快肌纤维的比例，而 BDNF 的缺失促进了快肌向慢肌的转变。本研究旨在评估 BDNF 基因 rs10501089 多态性（与血液 BDNF 水平相关）与肌肉纤维组成和力量型运动员状态之间的关系。肌肉纤维组成在 164 名活跃的个体（113 名男性，51 名女性）中进行了评估。比较了 508 名俄罗斯力量型运动员、178 名耐力运动员和 190 名对照组的 BDNF 基因型和等位基因频率。我们发现，携带 BDNF 小 A-等位基因（增加 BDNF 的等位基因）的个体的快肌纤维比例明显高于纯合 G-等位基因的个体（男性：64.3 [7.8] 比 50.3 [15.8]%，p=0.0015；所有受试者：64.1±7.9 比 49.6±14.7%，p=0.0002）。此外，A-等位基因与活跃受试者亚组的握力（n=83）（p=0.036）呈正相关，且与对照组相比，力量型运动员中 A-等位基因更为常见（7.7%比 2.4%，p=0.0001）。与对照组（比值比[OR]：3.43，p=0.00071）或耐力运动员（OR：2.36，p=0.0081）相比，A-等位基因（即 AA+AG 基因型）的存在而不是 GG 基因型增加了成为力量型运动员的优势比。总之，rs10501089 A-等位基因与快肌纤维比例增加和握力增强有关，这可能部分解释了 AA/AG 基因型与力量型运动员状态的关系。
