Franks S, Mason H D, Polson D W, Winston R M, Margara R, Reed M J
Department of Obstetrics and Gynaecology, St Mary's Hospital Medical School, London, UK.
Hum Reprod. 1988 May;3(4):531-4. doi: 10.1093/oxfordjournals.humrep.a136739.
Polycystic ovary syndrome is the most important cause of chronic anovulation. In women who fail to respond to clomiphene, low-dose FSH given in a step-wise fashion can induce normal follicular growth and ovulation. The failure of the action of endogenous FSH in these women may be related to reduced biological activity of circulating FSH, but may also involve inhibition of its action at follicular level by polypeptide growth factors such as EGF.
多囊卵巢综合征是慢性无排卵的最重要原因。对于克罗米芬治疗无效的女性，逐步给予低剂量促卵泡生成素（FSH）可诱导正常卵泡生长和排卵。这些女性体内内源性FSH作用失效可能与循环中FSH生物活性降低有关，但也可能涉及诸如表皮生长因子（EGF）等多肽生长因子在卵泡水平对其作用的抑制。
