Kamrava M M, Seibel M M, Berger M J, Thompson I, Taymor M L
Fertil Steril. 1982 Apr;37(4):520-3. doi: 10.1016/s0015-0282(16)46159-5.
Low doses of follicle-stimulating hormone (FSH) were administered once daily to two consecutive patients with polycystic ovarian disease (PCOD) for therapy of infertility. Serial blood samples were obtained for gonadotropins and ovarian steroid determinations during the period of FSH administration. Exogenous FSH resulted in an initial and concomitant decrease in serum androstenedione (A), estrone (E1), and luteinizing hormone (LH), with an increase in estradiol (E2) and FSH. Subsequent changes in the above-mentioned hormonal levels were typical of a normal ovulatory cycle, with the exception of FSH, which continued to rise in the second half of the follicular phase. This was attributed to the exogenous administration of FSH. Both patients became pregnant in their first induced ovulatory cycle by administration of chronic low-dose FSH. These preliminary data demonstrate (1) a correction of the biochemical imbalance characteristic of PCOD, (2) successful ovulation induction, and (3) restoration of fertility in PCOD treated with chronic low-dose FSH.
对两名连续的多囊卵巢疾病（PCOD）不孕患者每天一次给予低剂量促卵泡激素（FSH）进行不孕症治疗。在给予FSH期间采集系列血样以测定促性腺激素和卵巢类固醇。外源性FSH导致血清雄烯二酮（A）、雌酮（E1）和促黄体生成素（LH）最初同时下降，而雌二醇（E2）和FSH升高。上述激素水平随后的变化是正常排卵周期的典型变化，但FSH除外，其在卵泡期后半期持续升高。这归因于外源性给予FSH。两名患者通过给予慢性低剂量FSH在其第一个诱导排卵周期均成功怀孕。这些初步数据表明：（1）纠正了PCOD特有的生化失衡；（2）成功诱导排卵；（3）慢性低剂量FSH治疗的PCOD恢复了生育能力。
