Akpinar Merve, Temel Farabi, Tabakci Begum, Ozcelik Egemen, Tabakci Mustafa
Konya Technical University, Department of Chemical Engineering, 42130, Konya, Turkey; Selçuk University, Department of Chemical Engineering, 42130, Konya, Turkey.
Selçuk University, Department of Chemistry, 42130, Konya, Turkey.
Anal Biochem. 2019 Oct 15;583:113373. doi: 10.1016/j.ab.2019.113373. Epub 2019 Jul 22.
This paper describes the synthesis of new chiral calix [4]arene derivative having (R)-2-phenylglycinol moiety (compound 6), and its chiral recognition studies for ascorbic acid (AA) enantiomers by using Quartz Crystal Microbalance (QCM). Initial experiments indicated that the outstanding selective chiral recognition (α) was observed as 2.61 for l-enantiomer of AA. The sensitivity (S) and the limit of detection (LOD) values for L-AA were calculated as 0.0226 Hz/μM and 0.63 μM, respectively. Furthermore, the sorption behavior and mechanism of AA onto compound 6 film were evaluated and the sorption data exhibited a good correlation with the Freundlich isotherm models. The maximum uptake of L-AA by the sensor was found as 5895.76 mg/g. In conclusion, chiral recognition of AA enantiomers as real-time, sensitive, selective and effective was performed by a calixarene derivative coated QCM sensor.
本文描述了具有（R）-2-苯基甘醇部分的新型手性杯[4]芳烃衍生物（化合物6）的合成，以及使用石英晶体微天平（QCM）对其对抗坏血酸（AA）对映体的手性识别研究。初步实验表明，对于AA的L-对映体，观察到出色的选择性手性识别（α）为2.61。计算出L-AA的灵敏度（S）和检测限（LOD）值分别为0.0226 Hz/μM和0.63 μM。此外，评估了AA在化合物6膜上的吸附行为和机理，吸附数据与Freundlich等温线模型具有良好的相关性。传感器对L-AA的最大吸附量为5895.76 mg/g。总之，通过杯芳烃衍生物涂层的QCM传感器实现了对AA对映体的实时、灵敏、选择性和有效的手性识别。
