Federal University of Goiás, Institute of Tropical Pathology and Public Health, Goiânia, GO, Brazil.
Federal University of Goiás, Faculty of Nursing, Goiânia, GO, Brazil.
Braz J Infect Dis. 2019 Jul-Aug;23(4):271-273. doi: 10.1016/j.bjid.2019.06.008. Epub 2019 Jul 22.
To assess the prevalence of hepatitis C virus infection among men who have sex with men (MSM) in Central Brazil, a cross-sectional study was conducted in the City of Goiânia, Central Brazil, using Respondent-Driven Sampling (RDS). All serum samples were tested for anti-HCV and also for alanine aminotransferase (ALT). Anti-HCV positive samples and/or those with elevated ALT were tested for HCV RNA and genotyped. Of the 522 participants, four were found to be anti-HCV positive, and one was also HCV RNA positive (active HCV infection). Elevated ALT was found in 14 individuals. Of these, one showed evidence of acute HCV infection (HCV RNA positive and anti-HCV negative). Therefore, five MSM were positive for either anti-HCV and/or HCV RNA, giving a crude overall HCV prevalence of 1.0%; 1.3% (95% CI: 0.3-5.5) after being weighted by RDSAT. All five individuals reported high-risk sexual behaviors, including two who showed evidence of active HCV infection (genotype 1, subtypes 1a and 1b). Although the study population reported high-risk sexual practices, HCV infection was not more frequent in MSM than in the general Brazilian population.
为评估巴西中南部男男性行为者（MSM）中丙型肝炎病毒（HCV）感染的流行率，采用基于应答者驱动抽样法（RDS）在巴西中南部戈亚尼亚市开展了一项横断面研究。所有血清样本均进行抗-HCV 检测，同时检测丙氨酸氨基转移酶（ALT）。抗-HCV 阳性样本和/或 ALT 升高的样本进行 HCV RNA 检测和基因分型。在 522 名参与者中，有 4 名抗-HCV 阳性，1 名 HCV RNA 阳性（活动性 HCV 感染）。有 14 名 ALT 升高。其中，1 名急性 HCV 感染（HCV RNA 阳性而抗-HCV 阴性）。因此，5 名 MSM 抗-HCV 和/或 HCV RNA 阳性，粗总体 HCV 流行率为 1.0%；经 RDSAT 加权后为 1.3%（95%CI：0.3-5.5）。所有 5 名个体均报告了高风险性行为，包括 2 名有活动性 HCV 感染证据的个体（基因型 1，1a 和 1b 亚型）。尽管研究人群报告了高风险性行为，但 MSM 中的 HCV 感染并不比巴西普通人群更常见。
