NFκB1 启动子和 NFκBIA 基因多态性与 HIV 感染者抗 HHV-8 抗体的产生有关。

Association of polymorphisms in NFκB1 promoter and NFκBIA gene with the development of antibodies against HHV-8 in HIV-infected individuals.

机构信息

Virology Sector, Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Pernambuco, Brazil.

Virology Sector, Department of Preventive Veterinary Medicine, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.

出版信息

Virology. 2019 Sep;535:255-260. doi: 10.1016/j.virol.2019.07.011. Epub 2019 Jul 10.

DOI:10.1016/j.virol.2019.07.011

PMID:31344550

Abstract

Human gammaherpesvirus 8 (HHV-8) is the etiologic agent of Kaposi's sarcoma, multicentric Castleman's disease and primary effusion lymphoma. Like other herpesviruses, the HHV-8 may exhibit latent or lytic cycle, both regulated by viral and host factors. Regarding host factors, we analysed the association of polymorphisms in NFkB1 promoter (NFkB1-94 ins/del ATTG) and NFκBIA gene (NFκBIA 3'UTR A→G) with the development of antibodies against latent or lytic antigens from HHV-8. The ins/del [OR 7.9 (95% CI 3.3-19.1), p < 0.001], AG [OR 12.3 (95% CI 4.3-34.9) p < 0.001], GG [OR 9.4 (95% CI 3.2-27.9), p < 0.001], ins/del + AG [OR 94.5 (95% CI 9.6-924.4), <0.0001], ins/del + GG [OR 50.4 (95% CI 5.2-482.2, p < 0.0001] and G allele [OR 3.3 (95% CI 2.0-5.6), p < 0.001] were strongly related with the presence of antibodies to lytic antigens. This is the first association of polymorphisms in NFκB1 promoter and NFκBIA gene with the development of antibodies against HHV-8.

摘要

人类γ疱疹病毒 8（HHV-8）是卡波西肉瘤、多中心卡斯特曼病和原发性渗出性淋巴瘤的病原体。与其他疱疹病毒一样，HHV-8 可能表现出潜伏或裂解周期，这两个周期都受到病毒和宿主因素的调节。关于宿主因素，我们分析了 NFkB1 启动子（NFkB1-94 ins/del ATTG）和 NFκBIA 基因（NFκBIA 3'UTR A→G）多态性与抗 HHV-8 潜伏或裂解抗原抗体发展之间的关联。ins/del [OR 7.9（95% CI 3.3-19.1），p < 0.001]、AG [OR 12.3（95% CI 4.3-34.9），p < 0.001]、GG [OR 9.4（95% CI 3.2-27.9），p < 0.001]、ins/del + AG [OR 94.5（95% CI 9.6-924.4），<0.0001]、ins/del + GG [OR 50.4（95% CI 5.2-482.2，p < 0.0001]和 G 等位基因 [OR 3.3（95% CI 2.0-5.6），p < 0.001]与抗裂解抗原抗体的存在密切相关。这是 NFkB1 启动子和 NFκBIA 基因多态性与抗 HHV-8 抗体发展之间的首次关联。