Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Casilla 306, Santiago 6094411, Chile.
Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Casilla 306, Santiago 6094411, Chile.
Spectrochim Acta A Mol Biomol Spectrosc. 2020 Jan 5;224:117372. doi: 10.1016/j.saa.2019.117372. Epub 2019 Jul 8.
Sensing the most toxic heavy metal (mercury) has attracted a lot of attention in recent years due to its extreme harmfulness to both human health and the environment. Thus, we reported herein the synthesis, spectroscopic and kinetic characterization, and biological evaluation of a new thioxothiazolidin coumarin derivative (ILA92), which undergoes a desulfurization reaction induced by mercuric ions (Hg). This process is the origin of a selective sensing of Hg ions in aqueous solution by colorimetric and fluorescent methods. Furthermore, the probe showed great potential for imaging Hg in living cells.
近年来，由于汞（最具毒性的重金属之一）对人类健康和环境具有极大的危害性，因此对其进行检测受到了广泛关注。在此，我们报道了一种新的硫代噻唑烷并香豆素衍生物（ILA92）的合成、光谱和动力学特性以及生物评价，该衍生物可与汞离子（Hg）发生脱硫反应。这一过程是通过比色法和荧光法在水溶液中选择性检测汞离子的根源。此外，该探针在活细胞中成像汞方面具有很大的应用潜力。
