Jost Wolfgang H, Bäumer Tobias, Laskawi Rainer, Spittau Björn, Steffen Armin, Winterholler Martin
Parkinson-Klinik Ortenau, Wolfach.
Institut für Neurogenetik, Universität zu Lübeck.
Fortschr Neurol Psychiatr. 2019 Oct;87(10):554-563. doi: 10.1055/a-0958-2417. Epub 2019 Jul 25.
The most important salivary glands are the paired parotid and submandibular glands. Adults produce 1 to 1.5 liters of saliva which are then regularly swallowed. When the act of swallowing is disturbed, salivation occurs. More rarely, the cause can be found in increased saliva production, for example, when caused through medication. Sialorrhea impairs the quality of life substantially and is frequently often socially stigmatizing. Therapy includes conservative measures such as functional dysphagia therapy, oral or transdermal application of anticholinergics, as well as, in selected cases, radiation and surgical measures. Over the last 20 years local injection of botulinum toxin has been successfully applied in the treatment of this condition. With approval of this therapy by the European agencies, this measure will become the therapy of choice for pronounced therapy-resistant sialorrhea.
最重要的唾液腺是成对的腮腺和下颌下腺。成年人每天分泌1至1.5升唾液，这些唾液随后会被定期吞咽。当吞咽行为受到干扰时，就会发生流涎。更罕见的情况是，病因可能是唾液分泌增加，例如由药物引起。流涎严重影响生活质量，并且常常在社会上令人感到羞耻。治疗方法包括保守措施，如功能性吞咽困难治疗、口服或经皮应用抗胆碱能药物，以及在某些特定情况下采取放射和手术措施。在过去20年中，局部注射肉毒杆菌毒素已成功应用于这种病症的治疗。随着欧洲机构批准这种疗法，这一措施将成为治疗严重难治性流涎的首选疗法。
