个性化营养在慢性退行性疾病中的作用。
Role of Personalized Nutrition in Chronic-Degenerative Diseases.
机构信息
Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
School of Specialization in Food Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
出版信息
Nutrients. 2019 Jul 24;11(8):1707. doi: 10.3390/nu11081707.
Human nutrition is a branch of medicine based on foods biochemical interactions with the human body. The phenotypic transition from health to disease status can be attributed to changes in genes and/or protein expression. For this reason, a new discipline has been developed called "-omic science". In this review, we analyzed the role of "-omics sciences" (nutrigenetics, nutrigenomics, proteomics and metabolomics) in the health status and as possible therapeutic tool in chronic degenerative diseases. In particular, we focused on the role of nutrigenetics and the relationship between eating habits, changes in the DNA sequence and the onset of nutrition-related diseases. Moreover, we examined nutrigenomics and the effect of nutrients on gene expression. We perused the role of proteomics and metabolomics in personalized nutrition. In this scenario, we analyzed also how dysbiosis of gut microbiota can influence the onset and progression of chronic degenerative diseases. Moreover, nutrients influencing and regulating gene activity, both directly and indirectly, paves the way for personalized nutrition that plays a key role in the prevention and treatment of chronic degenerative diseases.
人类营养学是一门基于食物与人体生化相互作用的医学分支。从健康到疾病状态的表型转变可归因于基因和/或蛋白质表达的变化。出于这个原因，已经开发出了一个新的学科，称为“组学科学”。在这篇综述中，我们分析了“组学科学”（营养遗传学、营养基因组学、蛋白质组学和代谢组学）在健康状态中的作用以及作为慢性退行性疾病可能的治疗工具。特别是，我们专注于营养遗传学的作用以及饮食习惯、DNA 序列变化和营养相关疾病发病之间的关系。此外，我们研究了营养基因组学和营养素对基因表达的影响。我们研究了蛋白质组学和代谢组学在个性化营养中的作用。在这种情况下，我们还分析了肠道微生物组的失调如何影响慢性退行性疾病的发生和进展。此外，营养物质直接和间接影响和调节基因活性，为个性化营养铺平了道路，个性化营养在慢性退行性疾病的预防和治疗中起着关键作用。
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