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Monoclonal antibodies to the rough lipopolysaccharide of Neisseria meningitidis protect infant rats from meningococcal infection.

作者信息

Saukkonen K, Leinonen M, Käyhty H, Abdillahi H, Poolman J T

机构信息

National Public Health Institute, Helsinki, Finland.

出版信息

J Infect Dis. 1988 Jul;158(1):209-12. doi: 10.1093/infdis/158.1.209.

DOI:10.1093/infdis/158.1.209
PMID:3134492
Abstract
摘要

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1
Monoclonal antibodies to the rough lipopolysaccharide of Neisseria meningitidis protect infant rats from meningococcal infection.
J Infect Dis. 1988 Jul;158(1):209-12. doi: 10.1093/infdis/158.1.209.
2
Highly conserved Neisseria meningitidis inner-core lipopolysaccharide epitope confers protection against experimental meningococcal bacteremia.高度保守的脑膜炎奈瑟菌内核脂多糖表位赋予针对实验性脑膜炎球菌血症的保护作用。
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Functional activities of monoclonal antibodies to the O side chain of Escherichia coli lipopolysaccharides in vitro and in vivo.大肠杆菌脂多糖O侧链单克隆抗体在体内外的功能活性
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Naturally-occurring human serum antibodies to inner core lipopolysaccharide epitopes of Neisseria meningitidis protect against invasive meningococcal disease caused by isolates displaying homologous inner core structures.针对脑膜炎奈瑟菌内核脂多糖表位的天然存在的人血清抗体,可预防由显示同源内核结构的分离株引起的侵袭性脑膜炎球菌病。
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[Neisseria meningitidis. The pathophysiological role of lipopolysaccharides in association with meningococcal disease and septic shock].[脑膜炎奈瑟菌。脂多糖在脑膜炎球菌病和感染性休克中的病理生理作用]
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Human monoclonal antibody with protective activity for Escherichia coli K1 and Neisseria meningitidis group B infections.对大肠杆菌K1和B群脑膜炎奈瑟菌感染具有保护活性的人单克隆抗体。
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Inhibition of the alternative pathway of nonhuman infant complement by porin B2 contributes to virulence of Neisseria meningitidis in the infant rat model.孔蛋白 B2 抑制非人婴儿补体替代途径有助于脑膜炎奈瑟菌在婴儿鼠模型中的毒力。
Infect Immun. 2014 Jun;82(6):2574-84. doi: 10.1128/IAI.01517-14. Epub 2014 Mar 31.
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A glycoconjugate vaccine for Neisseria meningitidis induces antibodies in human infants that afford protection against meningococcal bacteremia in a neonate rat challenge model.一种针对脑膜炎奈瑟菌的糖缀合物疫苗可在人类婴儿中诱导产生抗体,这些抗体在新生大鼠攻毒模型中能提供针对脑膜炎球菌血症的保护作用。
Infect Immun. 2002 Dec;70(12):6576-82. doi: 10.1128/IAI.70.12.6576-6582.2002.
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Cross-reactive polyclonal antibodies to the inner core of lipopolysaccharide from Neisseria meningitidis.
针对脑膜炎奈瑟菌脂多糖内核的交叉反应性多克隆抗体。
Infect Immun. 2002 Mar;70(3):1293-300. doi: 10.1128/IAI.70.3.1293-1300.2002.
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Differences in surface expression of NspA among Neisseria meningitidis group B strains.B群脑膜炎奈瑟菌菌株间NspA表面表达的差异。
Infect Immun. 1999 Nov;67(11):5664-75. doi: 10.1128/IAI.67.11.5664-5675.1999.
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Infect Immun. 1994 May;62(5):1566-75. doi: 10.1128/iai.62.5.1566-1575.1994.
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Animal models for pathogenic Neisseria species.致病性奈瑟菌属物种的动物模型。
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Purification, cyanogen bromide cleavage, and amino terminus sequencing of class 1 and class 3 outer membrane proteins of meningococci.脑膜炎球菌1类和3类外膜蛋白的纯化、溴化氰裂解及氨基末端测序
Infect Immun. 1989 Mar;57(3):1005-7. doi: 10.1128/iai.57.3.1005-1007.1989.
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Toxicity and immunogenicity of Neisseria meningitidis lipopolysaccharide incorporated into liposomes.掺入脂质体的脑膜炎奈瑟菌脂多糖的毒性和免疫原性。
Infect Immun. 1992 Sep;60(9):3897-903. doi: 10.1128/iai.60.9.3897-3903.1992.