DMC Healthcare Ltd, London, England, UK.
Clin Dermatol. 2019 Jul-Aug;37(4):320-325. doi: 10.1016/j.clindermatol.2019.04.011. Epub 2019 Apr 26.
Aging is the result of two overlapping processes, "intrinsic" and "extrinsic." Intrinsic structural changes occur as a consequence of physiologic aging and are genetically determined; extrinsic relates to exposure to harmful events and habits, like smoking, bad diet, alcohol consumption, lack of sleep, stress, sun exposure, environmental pollution, etc. Aging may be decelerated by improving bad habits or treating signs of aging with various esthetic methods, food supplements, and antioxidants. It is believed that we cannot stop aging entirely due to the intrinsic part, which leads to irreversible cell damage, as well as tissue and organ damage due to their limited ability to regenerate. Stem cells and their ability to exhibit telomerase activity, to self-renew, and to differentiate into all three embryonic tissues challenges aging as a process, which is not inevitable and can even possibly be reversed. Stem cells can promote regeneration of aged tissues and organs by replacing apoptotic and necrotic cells with healthy ones. In addition, they can have antiinflammatory and antiapoptotic properties by paracrine-secreting growth factors and cytokines on the site of administration. Autologous adipose-derived stem cells are the most promising because they can be easily harvested in huge numbers with minimally invasive liposuction and, as such, represent a powerful tool in anti-aging and regenerative medicine. In this contribution, the author discusses their properties and application in clinical practice.
衰老是两个重叠过程的结果，“内在”和“外在”。内在结构变化是生理衰老的结果，由遗传决定；外在与暴露于有害事件和习惯有关，如吸烟、不良饮食、饮酒、缺乏睡眠、压力、阳光照射、环境污染等。通过改善不良习惯或用各种美容方法、膳食补充剂和抗氧化剂来治疗衰老迹象，可以减缓衰老。由于内在部分会导致不可逆转的细胞损伤，以及由于其有限的再生能力导致的组织和器官损伤，因此人们认为我们不能完全阻止衰老。干细胞及其表现端粒酶活性、自我更新并分化为所有三种胚胎组织的能力挑战了衰老作为一个不可避免的过程，甚至可能会被逆转。干细胞可以通过用健康细胞替代凋亡和坏死细胞来促进衰老组织和器官的再生。此外，它们可以通过旁分泌生长因子和细胞因子在给药部位发挥抗炎和抗细胞凋亡作用。自体脂肪来源干细胞是最有前途的，因为它们可以通过微创吸脂术轻松大量采集，因此代表了抗衰老和再生医学的有力工具。在这篇文章中，作者讨论了它们的特性及其在临床实践中的应用。
