Zhu Mingsheng, Meng Ping, Ling Xian, Zhou Lili
State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Nephrology, Huadu District People's Hospital, Southern Medical University, Guangzhou, China.
Ther Adv Chronic Dis. 2020 Oct 13;11:2040622320964125. doi: 10.1177/2040622320964125. eCollection 2020.
Aging leads to a high burden on society, both medically and economically. Cellular senescence plays an essential role in the initiation of aging and age-related diseases. Recent studies have highlighted the therapeutic value of senescent cell deletion in natural aging and many age-related disorders. However, the therapeutic strategies for manipulating cellular senescence are still at an early stage of development. Among these strategies, therapeutic drugs that target cellular senescence are arguably the most highly anticipated. Many recent studies have demonstrated that a variety of drugs exhibit healthy aging effects. In this review, we summarize different types of drugs promoting healthy aging - such as senolytics, senescence-associated secretory phenotype (SASP) inhibitors, and nutrient signaling regulators - and provide an update on their potential therapeutic merits. Taken together, our review synthesizes recent advancements in the therapeutic potentialities of drugs promoting healthy aging with regard to their clinical implications.
衰老给社会带来了巨大的医学和经济负担。细胞衰老在衰老及与年龄相关疾病的发生过程中起着至关重要的作用。最近的研究凸显了清除衰老细胞在自然衰老和许多与年龄相关疾病中的治疗价值。然而，调控细胞衰老的治疗策略仍处于发展初期。在这些策略中，靶向细胞衰老的治疗药物无疑是最受期待的。最近的许多研究表明，多种药物具有促进健康衰老的作用。在本综述中，我们总结了不同类型的促进健康衰老的药物，如衰老细胞溶解剂、衰老相关分泌表型（SASP）抑制剂和营养信号调节剂，并介绍了它们潜在的治疗优势。综上所述，我们的综述综合了促进健康衰老药物治疗潜力方面的最新进展及其临床意义。
