Department of Endocrine Nephropathy, Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer Hospital, 400030, China.
Key Laboratory of Diagnostic Medicine (Ministry of Education) and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, 400016, China.
Mediators Inflamm. 2019 Jun 27;2019:6321427. doi: 10.1155/2019/6321427. eCollection 2019.
ANGPTL8 has been reported to be a regulator of lipid metabolism, and it is associated with insulin resistance (IR) and metabolic syndrome (MetS). We investigated whether ANGPTL8 plays a role in MetS.
ANGPTL8 and adiponectin concentrations were measured in PCOS patients with or without MetS and in their corresponding healthy controls. The association of circulating ANGPTL8 with adiponectin and other parameters was also examined.
Circulating ANGPTL8 concentrations were higher in PCOS women with MetS than in those without MetS and in the controls ( < 0.01). ANGPTL8 was positively correlated with age, BMI, FAT%, WHR, SBP, TG, FBG, HbA1c, Fins, and HOMA-IR (all < 0.01) in the study populations and negatively associated with adiponectin and -values ( < 0.001). In addition, ANGPTL8 was positively correlated with PRL, LH, TEST, and FAI and negatively correlated with SHBG (all < 0.01). ROC curve analyses showed that the AUC was 0.87 ( < 0.001), with a sensitivity of 92.4% and specificity of 75.4%, and the AUC was 0.82 ( < 0.01), with a sensitivity of 76.4% and specificity of 75.6%.
ANGPTL8 levels progressively decrease from PCOS patients with MetS to those without MetS and may be a serum marker associated with the degree of metabolic disorders.
ANGPTL8 已被报道为脂质代谢的调节剂，与胰岛素抵抗（IR）和代谢综合征（MetS）有关。我们研究了 ANGPTL8 是否在 MetS 中发挥作用。
在患有或不患有 MetS 的 PCOS 患者及其相应的健康对照者中测量了 ANGPTL8 和脂联素的浓度。还检查了循环 ANGPTL8 与脂联素和其他参数的相关性。
患有 MetS 的 PCOS 女性的循环 ANGPTL8 浓度高于无 MetS 者和对照组（<0.01）。在研究人群中，ANGPTL8 与年龄、BMI、FAT%、WHR、SBP、TG、FBG、HbA1c、Fins 和 HOMA-IR 呈正相关（均<0.01），与脂联素和 -值呈负相关（均<0.001）。此外，ANGPTL8 与 PRL、LH、TEST 和 FAI 呈正相关，与 SHBG 呈负相关（均<0.01）。ROC 曲线分析显示 AUC 为 0.87（<0.001），敏感性为 92.4%，特异性为 75.4%，AUC 为 0.82（<0.01），敏感性为 76.4%，特异性为 75.6%。
ANGPTL8 水平从患有 MetS 的 PCOS 患者逐渐降低到不患有 MetS 的患者，可能是与代谢紊乱程度相关的血清标志物。
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