New insights into ANGPTL8 in modulating the development of cardio-metabolic disorder diseases.

Dyslipidemia is being identified as the most important factors of several health problems, such as obesity, diabetes mellitus, and cardiovascular diseases (CVD), which are always grouped together as cardio-metabolic disorder diseases. Consistently, dyslipidemia has become one of the most rising crisis of general health. Recently, it is worth noting that both genome-wide association studies (GWAS) and experimental research are being taken advantage to elucidate the potential genetic mechanisms of dyslipidemia and to identify new gene loci which contribute to the development of cardio-metabolic disorder diseases. According to the results, both ANGPTL8 gene and ANGPTL8 protein has been shown to embrace vital functions in modulating serum glucose and lipid metabolism. In the current review, the modulatory effects of ANGPTL8 in cardio-metabolic disorder diseases were summarized. In addition, novel insights which elucidate the potential mechanisms whereby ANGPTL8 affects glucose and lipid metabolism were also provided.