Anderson Kara B, Holloway-Kew Kara L, Hans Didier, Kotowicz Mark A, Hyde Natalie K, Pasco Julie A
Deakin University, School of Medicine Geelong Australia.
Center of Bone Diseases, Bone & Joint Department Lausanne University Hospital Lausanne Switzerland.
JBMR Plus. 2019 Jan 15;3(6):e10133. doi: 10.1002/jbm4.10133. eCollection 2019 Jun.
Trabecular bone score (TBS) is a novel method for indirectly assessing trabecular microarchitecture at the lumbar spine, providing information complementary to areal BMD. However, limited reference ranges exist for the normative distribution of TBS, particularly in men. The aim of this study was to develop such a reference range in Australian men and women. This study included 894 men and 682 women (aged 24 to 98 years) enrolled in the Geelong Osteoporosis Study. TBS was determined retrospectively by analysis of lumbar spine DXA scans (Lunar Prodigy) using TBS iNsight software (version 2.2). Multivariable regression techniques were used to determine best-fit models for TBS incorporating age, height, and weight. Age-related differences in TBS were best modelled with a linear relationship in men and a cubic relationship in women. Combined best-fit models for TBS included age and weight in men, and age and height in women. This study provides normative reference ranges for TBS in Australian men and women, and further indicates that TBS may identify individuals at risk for fracture despite normal BMD. © 2018 The Authors. Published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research.
骨小梁评分（TBS）是一种间接评估腰椎骨小梁微结构的新方法，可提供与骨面积密度（BMD）互补的信息。然而，TBS的正常分布参考范围有限，尤其是在男性中。本研究的目的是建立澳大利亚男性和女性的此类参考范围。本研究纳入了894名男性和682名女性（年龄在24至98岁之间），他们均参与了吉朗骨质疏松症研究。使用TBS iNsight软件（版本2.2）通过分析腰椎双能X线吸收测定（DXA）扫描（Lunar Prodigy）回顾性确定TBS。采用多变量回归技术来确定纳入年龄、身高和体重的TBS最佳拟合模型。男性中TBS与年龄的差异以线性关系建模最佳，女性则以三次方关系建模最佳。TBS的联合最佳拟合模型在男性中包括年龄和体重，在女性中包括年龄和身高。本研究提供了澳大利亚男性和女性TBS的正常参考范围，并进一步表明TBS可能识别出骨密度正常但有骨折风险的个体。© 2018作者。由Wiley Periodicals, Inc.代表美国骨与矿物质研究学会出版。
