一氧化氮在大脑中的信号传递及其对身体功能的控制。
Nitric oxide signalling in the brain and its control of bodily functions.
机构信息
Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, UMR-S 1172, Lille, France.
School of Medicine, University of Lille, Lille, France.
出版信息
Br J Pharmacol. 2020 Dec;177(24):5437-5458. doi: 10.1111/bph.14800. Epub 2019 Sep 8.
Abstract
Nitric oxide (NO) is a versatile molecule that plays key roles in the development and survival of mammalian species by endowing brain neuronal networks with the ability to make continual adjustments to function in response to moment-to-moment changes in physiological input. Here, we summarize the progress in the field and argue that NO-synthetizing neurons and NO signalling in the brain provide a core hub for integrating sensory- and homeostatic-related cues, control key bodily functions, and provide a potential target for new therapeutic opportunities against several neuroendocrine and behavioural abnormalities.
摘要
一氧化氮（NO）是一种多功能分子，通过赋予大脑神经网络持续调整功能的能力，以响应生理输入的瞬息万变，从而在哺乳动物物种的发育和生存中发挥关键作用。在这里，我们总结了该领域的进展，并认为大脑中合成 NO 的神经元和 NO 信号为整合感觉和动态平衡相关线索、控制关键身体功能提供了核心枢纽，并为针对几种神经内分泌和行为异常的新治疗机会提供了潜在目标。
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