Department of Evidence-Based Medicine, School of Public Health, Southwest Medical University, Luzhou, Sichuan, China.
Department of Rheumatology and Immunology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Int J Rheum Dis. 2019 Sep;22(9):1598-1606. doi: 10.1111/1756-185X.13654. Epub 2019 Jul 25.
This study aimed to discuss the relationship between interferon regulatory factor (IRF)5 gene rs2004640 T/G polymorphism and systemic lupus erythematosus (SLE) susceptibility.
A meta-analysis was calculated on the association between rs2004640 polymorphism and SLE by allelic contrast (T vs G), additive model (TT vs GG), recessive model (TT vs TG + GG) and dominant model (TT + TG vs GG).
A total of 28 comparisons were identified, including 11 228 SLE cases and 14 374 controls. Meta-analysis revealed a significant association between allele T and SLE in overall populations (odds ratio [OR] = 1.393, 95% CI: 1.276-1.522, P < 0.001). Stratification by ethnicity indicated strong associations between T allele and SLE in Asians, Europeans and Latin Americans (OR = 1.256, 95% CI: 1.073-1.469, P = 0.004; OR = 1.338, 95% CI: 1.080-1.659, P = 0.008; OR = 1.853, 95% CI: 1.488-2.308, P < 0.001). Results also showed significant associations between the additive model and SLE in all subjects and Asians (OR = 1.999, 95% CI: 1.442-2.771, P < 0.001; OR = 1.544, 95% CI: 1.009-2.362, P < 0.045). In addition, we found significant associations between the dominant model and SLE in all populations and Asians (OR = 1.521, 95% CI: 1.257-1.841, P < 0.001; OR = 1.270, 95% CI: 1.136-1.421, P < 0.001). A marginal association was detected between the recessive mode and SLE in overall subjects (OR = 1.480, 95% CI: 1.022-2.144, P = 0.038).
The current study suggested that individuals carrying rs2004640 T allele correlated with a high risk of SLE, and the IRF5 rs2004640 polymorphism was associated with SLE susceptibility.
本研究旨在探讨干扰素调节因子（IRF）5 基因 rs2004640T/G 多态性与系统性红斑狼疮（SLE）易感性之间的关系。
通过等位基因对比（T 对 G）、加性模型（TT 对 GG）、隐性模型（TT 对 TG+GG）和显性模型（TT+TG 对 GG），对 rs2004640 多态性与 SLE 之间的关联进行荟萃分析。
共纳入 28 项比较，包括 11228 例 SLE 病例和 14374 例对照。荟萃分析显示，在总体人群中，等位基因 T 与 SLE 存在显著相关性（比值比[OR] = 1.393，95%可信区间：1.276-1.522，P<0.001）。按种族分层，在亚洲人、欧洲人和拉丁美洲人中，T 等位基因与 SLE 之间存在强烈关联（OR = 1.256，95%可信区间：1.073-1.469，P=0.004；OR = 1.338，95%可信区间：1.080-1.659，P=0.008；OR = 1.853，95%可信区间：1.488-2.308，P<0.001）。结果还显示，在所有受试者和亚洲人中，加性模型与 SLE 之间存在显著相关性（OR = 1.999，95%可信区间：1.442-2.771，P<0.001；OR = 1.544，95%可信区间：1.009-2.362，P<0.045）。此外，我们发现显性模型与所有人群和亚洲人中的 SLE 之间存在显著相关性（OR = 1.521，95%可信区间：1.257-1.841，P<0.001；OR = 1.270，95%可信区间：1.136-1.421，P<0.001）。在总体受试者中，隐性模型与 SLE 之间存在边缘相关性（OR = 1.480，95%可信区间：1.022-2.144，P=0.038）。
本研究表明，携带 rs2004640T 等位基因的个体与 SLE 发生的高风险相关，IRF5 rs2004640 多态性与 SLE 易感性相关。
