Glatz Wilfried, Glatz Marlene, List Wolfgang, Wallisch Fabian, Steinwender Gernot, Ivastinovic Domagoj, Wedrich Andreas
Department of Ophthalmology, Medical University Graz, Graz, Austria.
Heliyon. 2024 Jul 24;10(15):e35094. doi: 10.1016/j.heliyon.2024.e35094. eCollection 2024 Aug 15.
The retina is supplied with blood through superficial and deep capillary systems. Paracentral acute middle maculopathy (PAMM) is a relatively new terminology based on pathognomonic findings in the spectral-domain optical coherence tomography (SD-OCT). A connection with various retinal vascular diseases has been described, which is indicative of an ischemic etiology. The objective of our study is to contribute to the understanding of PAMM as either an isolated phenomenon or one associated with underlying health issues. We hope to contribute to a better understanding of this medical condition for potential future clinical approaches.
This is a retrospective chart review performed at the Department of Ophthalmology of the Medical University of Graz. We reviewed the medical charts of patients who presented at our ophthalmological emergency department between January and April 2023. Patients with a diagnosis of PAMM, verified by a retina specialist, were included in our analysis.
Overall, five eyes of five female patients were enrolled. The patients' age averaged 28.6 ± 10.4 years (16-44), with a median visual acuity at the initial presentation of 0 logMAR (1.9-0). Multimodal imaging, including SD-OCT, OCT angiography, fluorescein angiography and fundus photography, was performed. A complete blood count and a comprehensive internal medicine examination were performed, yielding no underlying comorbidities.
Our study shows that isolated PAMM may occur as an idiopathic exclusion diagnosis in otherwise healthy adults after further investigation yielded no results. However, due to the potential vascular comorbidities shown in previous studies, a thorough investigation should still be carried out.
视网膜通过浅表和深部毛细血管系统供血。黄斑中心凹旁急性中层病变（PAMM）是基于光谱域光学相干断层扫描（SD-OCT）的特征性表现而提出的一个相对较新的术语。已描述了它与各种视网膜血管疾病的关联，这表明其病因是缺血性的。我们研究的目的是有助于理解PAMM是一种孤立现象还是与潜在健康问题相关的现象。我们希望能为更好地理解这种病症以用于未来潜在的临床方法做出贡献。
这是一项在格拉茨医科大学眼科进行的回顾性病历审查。我们回顾了2023年1月至4月在我们眼科急诊科就诊的患者的病历。经视网膜专科医生确诊为PAMM的患者被纳入我们的分析。
总体而言，纳入了5名女性患者的5只眼。患者平均年龄为28.6 ± 10.4岁（16 - 44岁），初诊时的中位视力为0 logMAR（1.9 - 0）。进行了包括SD-OCT、OCT血管造影、荧光素血管造影和眼底摄影在内的多模态成像检查。进行了全血细胞计数和全面的内科检查，未发现潜在的合并症。
我们的研究表明，在进一步检查未发现结果后，孤立性PAMM可能作为特发性排除诊断出现在其他方面健康的成年人中。然而，鉴于先前研究中显示的潜在血管合并症，仍应进行全面调查。
