Perez-D'Gregorio R E, Miller R K
Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, New York 14642.
Teratology. 1988 Apr;37(4):307-16. doi: 10.1002/tera.1420370404.
The effects of multiple maternal subcutaneous injections of tellurium dioxide (TeO2) suspended in olive oil (0-1,000 mumol/kg) from day 15 to day 19 of gestation were evaluated in the Wistar rat. External and internal soft-tissue examinations were performed on day 20 fetuses. Multiple maternal injections, at doses higher than 10 mumol/kg, resulted in a dose-related appearance of hydrocephalus, edema, exophthalmia, ocular hemorrhage, umbilical hernia, undescended testis, and small kidneys in fetuses on day 20 of gestation. At 500 mumol/kg, reduction in maternal weight gain was also observed. At this level, the incidence of the above anomalies was 100%. The 100 mumol/kg dose of Te, which did not produce apparent maternal toxic responses, resulted in a 100% incidence of hydrocephalus and edema but no fetal mortality. Thus, tellurium can be teratogenic to the rat fetus without concomitant maternal toxicity. Also, the fetal period may be more sensitive than the organogenic period for the induction of hydrocephalus. Such evidence is consistent with the development of the choroid plexus and an effect of TeO2 on the production/resorption of cerebrospinal fluid.
在Wistar大鼠中评估了从妊娠第15天至第19天多次经皮下向母体注射悬浮于橄榄油中的二氧化碲（TeO₂，剂量为0 - 1000 μmol/kg）的影响。在妊娠第20天对胎儿进行了外部和内部软组织检查。多次向母体注射高于10 μmol/kg的剂量，导致妊娠第20天的胎儿出现与剂量相关的脑积水、水肿、眼球突出、眼内出血、脐疝、隐睾和小肾脏。在500 μmol/kg时，还观察到母体体重增加减少。在此水平，上述异常的发生率为100%。100 μmol/kg剂量的碲未产生明显的母体毒性反应，但导致脑积水和水肿的发生率为100%，且无胎儿死亡。因此，碲可对大鼠胎儿产生致畸作用而无母体毒性。此外，胎儿期对于脑积水的诱导可能比器官形成期更敏感。这些证据与脉络丛的发育以及TeO₂对脑脊液产生/吸收的影响是一致的。
