Wang Hui, Meng Guo-Liang, Zhang Chun-Teng, Wang Hao, Hu Mei, Long Yan, Hong Hao, Tang Su-Su
Department of Medical Technology, Taizhou Polytechnic College, Taizhou 225300, China.
School of Pharmacy, Nantong University, Nantong 226001, China.
J Asian Nat Prod Res. 2020 Sep;22(9):864-878. doi: 10.1080/10286020.2019.1642878. Epub 2019 Jul 26.
This study aimed to evaluate whether mogrol, a main bioactive ingredient of , could attenuate LPS-induced memory impairment in mice. The behavioral tests and immunohistochemical analysis and Western blot were performed. The present results showed that oral administration of mogrol (20, 40, 80 mg/kg) significantly improved LPS-induced memory impairment in mice. The results also indicated that mogrol treatment significantly reduced the number of Iba1-positive cells, the nuclear NF-κB p65 and levels of TNF-α, IL-1β and IL-6 both in the hippocampus and frontal cortex of LPS-challenged mice. [Formula: see text].
本研究旨在评估罗汉果甜苷（罗汉果的主要生物活性成分）是否能减轻脂多糖诱导的小鼠记忆损伤。进行了行为测试、免疫组织化学分析和蛋白质印迹法。目前的结果表明，口服罗汉果甜苷（20、40、80毫克/千克）可显著改善脂多糖诱导的小鼠记忆损伤。结果还表明，罗汉果甜苷处理可显著减少脂多糖刺激小鼠海马体和额叶皮质中离子钙接头蛋白1阳性细胞的数量、核因子κB p65以及肿瘤坏死因子-α、白细胞介素-1β和白细胞介素-6的水平。[公式：见正文]
