College of Bioinformatics Science & Technology, Harbin Medical University, Harbin 150081, PR China.
School of Life Science, Faculty of Science, The Chinese University of Hong Kong, PR China.
Epigenomics. 2019 Aug;11(10):1177-1190. doi: 10.2217/epi-2018-0138. Epub 2019 Jul 26.
The potential functions and prognostic value of lincRNAs with co-methylation events are explored in 9 cancer types. Here, we evaluated the co-methylation events in promoter and gene-body regions between two lincRNAs across 9 cancer types by constructing a systematic biological framework. The co-methylation events in both promoter and gene-body regions tended to be highly cancer specific. Patient samples could be separated by tumor and normal types according to the eigengenes of universal co-methylation clusters. Functional enrichment results revealed the lincRNAs that brought promoter and gene-body co-methylation events that affected cancer progress through participating in different pathways and could serve as potential prognostic biomarkers. The study provides new insight into the epigenetic regulation in cancer and leads to a potential new direction for epigenetic biomarker discovery.
探讨了共甲基化事件相关 lincRNAs 的潜在功能和预后价值，涉及 9 种癌症类型。在这里，我们通过构建系统的生物学框架，评估了两种 lincRNAs 在启动子和基因体区域之间的共甲基化事件。启动子和基因体区域的共甲基化事件往往具有高度的癌症特异性。根据通用共甲基化簇的特征基因，可以根据肿瘤和正常类型对患者样本进行分离。功能富集结果显示，lincRNAs 通过参与不同的途径，带来启动子和基因体共甲基化事件，影响癌症进展，可以作为潜在的预后生物标志物。该研究为癌症中的表观遗传调控提供了新的见解，并为表观遗传生物标志物的发现开辟了一个潜在的新方向。
