原位光声成像检测半胱氨酸以揭示肺纤维化中 GSH 合成受限的机制。
In situ photoacoustic imaging of cysteine to reveal the mechanism of limited GSH synthesis in pulmonary fibrosis.
机构信息
College of Chemistry, Chemical Engineering and Materials Science, Institute of Biomedical Sciences, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, China.
出版信息
Chem Commun (Camb). 2019 Aug 21;55(65):9685-9688. doi: 10.1039/c9cc03814k. Epub 2019 Jul 26.
We developed a photoacoustic and fluorescent dual-mode imaging probe, CCYS, for the detection of cysteine with high selectivity and sensitivity in a living system for the first time. By using CCYS, we found that the limited synthesis of glutathione in pulmonary fibrosis was not caused by cysteine deficiency.
我们首次开发了一种光声和荧光双模成像探针 CCYS，用于在活体系统中高选择性和高灵敏度地检测半胱氨酸。通过使用 CCYS，我们发现肺纤维化中谷胱甘肽的有限合成不是由半胱氨酸缺乏引起的。
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