Lowe Christopher D, Brahe Catherine A, Green Brian, Lam Thomas K, Meyerle Jon H
Section of Dermatology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
Section of Dermatology, Walter Reed National Military Medical Center, Bethesda, Maryland; and Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, USA.
Cutis. 2019 Jun;103(6):E5-E7.
Bullous systemic lupus erythematosus (BSLE) is a rare complication of systemic lupus erythematosus (SLE) characterized by cutaneous vesicles and bullae with a primarily neutrophilic infiltrate on histopathology. Bullous SLE is a heterogeneous disease without pathognomonic clinical features, making the diagnosis and differentiation from other blistering diseases challenging. We present the case of a single patient with SLE in whom 3 different clinical appearances of BSLE manifested over 5 years. The cutaneous eruption dramatically improved with rituximab at the initial presentation and continued to respond to rituximab during subsequent flares over the subsequent 5 years.
大疱性系统性红斑狼疮（BSLE）是系统性红斑狼疮（SLE）的一种罕见并发症，其特征为皮肤水疱和大疱，组织病理学上主要为中性粒细胞浸润。大疱性SLE是一种异质性疾病，没有特征性的临床特征，这使得其诊断以及与其他水疱性疾病的鉴别具有挑战性。我们报告了一例SLE患者的病例，该患者在5年期间出现了3种不同临床表现的BSLE。初次就诊时，皮肤皮疹使用利妥昔单抗后显著改善，在随后的5年中，后续病情发作时继续对利妥昔单抗有反应。
