AP-HP (Assistance Publique-Hôpitaux de Paris), Department of Nephrology and Transplantation, Rare French Disease Centre "Idiopathic Nephrotic syndrome", Henri-Mondor/Albert-Chenevier Hospital, Créteil, France.
Inserm U955, Team 21, DHU VIC, Paris-Est University, Créteil, France.
Br J Haematol. 2019 Dec;187(5):676-680. doi: 10.1111/bjh.16113. Epub 2019 Jul 26.
The prognosis of sickle cell disease (SCD) patients who need dialysis is poor, but experience with kidney transplantation is limited. This study assessed the characteristics of 36 SCD patients undergoing renal transplantation. Immediate post-surgical complications occurred in 25% of cases. Cytomegalovirus and bacterial infections were frequently observed. Twelve patients died after a median follow-up period of 17·4 months. Overall patient survival was significantly lower in SCD than in the control group without significant difference for overall death-censored graft survival. Our data suggest that renal transplantation should be systematically considered in SCD patients with end-stage renal disease.
镰状细胞病（SCD）患者需要透析的预后较差，但肾移植经验有限。本研究评估了 36 例接受肾移植的 SCD 患者的特征。术后立即发生并发症的占 25%。巨细胞病毒和细菌感染很常见。12 例患者在中位随访 17.4 个月后死亡。总体患者生存率在 SCD 组显著低于对照组，但总死亡 censored 移植物生存率无显著差异。我们的数据表明，对于终末期肾病的 SCD 患者，应系统考虑肾移植。
