活检证实的小纤维神经病的纵向随访。

Longitudinal follow-up of biopsy-proven small fiber neuropathy.

机构信息

Department of Neurology, Cleveland Clinic, Cleveland, Ohio.

Department of Quantitative Health Sciences, Learner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

出版信息

Muscle Nerve. 2019 Oct;60(4):376-381. doi: 10.1002/mus.26648. Epub 2019 Aug 8.

DOI:10.1002/mus.26648

PMID:31348533

Abstract

INTRODUCTION

Little is published on the prognosis of small fiber neuropathy (SFN).

METHODS

A retrospective analysis of 101 patients with biopsy proven SFN.

RESULTS

Study participants included 87 patients with length-dependent SFN and 14 patients with non-length-dependent SFN. The average duration of symptoms was 3.2 years prior to SFN diagnosis, and the average follow-up duration after diagnosis was 6.2 years. Neuropathic pain was present in 98% of patients and in 84.2% of patients at the final visit. The average total number of pain medications ever used was 4.4 per patient. Signs of autonomic dysfunction were initially present in 24.8% of patients, but improved in most. Large fiber involvement was seen in 11.9% of patients. Small fiber neuropathy affected employment and ambulation status in 5.3% and 6.3% of patients, respectively.

DISCUSSION

Small fiber neuropathy tends to be stable and rarely affects ambulation and employment status. Effective pain control remains a challenge.

摘要

简介

有关小纤维神经病 (SFN) 的预后信息较少。

方法

对 101 例经活检证实的 SFN 患者进行回顾性分析。

结果

研究参与者包括 87 例长度依赖性 SFN 患者和 14 例非长度依赖性 SFN 患者。在 SFN 诊断前，症状平均持续 3.2 年，诊断后平均随访时间为 6.2 年。98%的患者存在神经病理性疼痛，84.2%的患者在最后一次就诊时存在神经病理性疼痛。平均每位患者使用的镇痛药总数为 4.4 种。最初有 24.8%的患者存在自主神经功能障碍的迹象，但大多数患者的情况有所改善。11.9%的患者存在大纤维受累。SFN 分别影响 5.3%和 6.3%的患者的就业和步行状态。