ILD Center of Excellence, Department of Pulmonology,St Antonius Hospital, CM, Nieuwegein, The Netherlands.
Department of Neurology, St Antonius Hospital, CM, Nieuwegein, The Netherlands.
J Neuromuscul Dis. 2021;8(2):185-207. doi: 10.3233/JND-200490.
Small fiber neuropathy (SFN) is a disorder of the small myelinated Aδ-fibers and unmyelinated C-fibers [5, 6]. SFN might affect small sensory fibers, autonomic fibers or both, resulting in sensory changes, autonomic dysfunction or combined symptoms [7]. As a consequence, the symptoms are potentially numerous and have a large impact on quality of life [8]. Since diagnostic methods for SFN are numerous and its pathophysiology complex, this extensive review focusses on categorizing all aspects of SFN as disease and its diagnosis. In this review, sensitivity in combination with specificity of different diagnostic methods are described using the areas under the curve. In the end, a diagnostic work-flow is suggested based on different phenotypes of SFN.
小纤维神经病（SFN）是一种小髓鞘 Aδ 纤维和无髓鞘 C 纤维的疾病[5,6]。SFN 可能影响小感觉纤维、自主纤维或两者都影响，导致感觉改变、自主功能障碍或合并症状[7]。因此，症状可能很多，对生活质量有很大影响[8]。由于 SFN 的诊断方法很多，其病理生理学也很复杂，因此，这篇广泛的综述重点关注将 SFN 的所有方面归类为疾病及其诊断。在本综述中，使用曲线下面积描述了不同诊断方法的敏感性与特异性。最后，根据 SFN 的不同表型提出了一种诊断工作流程。
