脑内皮屏障中的分子伴侣：神经毒性还是神经保护？
Molecular chaperones in the brain endothelial barrier: neurotoxicity or neuroprotection?
机构信息
INSERM Unité Mixte de Recherche (UMR) 1231, Institut Fédératif de Recherche en Santé-Sciences et Techniques de l'Information et de la Communication (IFR Santé-STIC), Faculté de Médecine, Université de Bourgogne Franche-Comté, Dijon, France.
出版信息
FASEB J. 2019 Nov;33(11):11629-11639. doi: 10.1096/fj.201900895R. Epub 2019 Jul 26.
Abstract
Brain microvascular endothelial cells (BMECs) interact with astrocytes and pericytes to form the blood-brain barrier (BBB). Their compromised function alters the BBB integrity, which is associated with early events in the pathogenesis of cancer, neurodegenerative diseases, and epilepsy. Interestingly, these conditions also induce the expression of heat shock proteins (HSPs). Here we review the contribution of major HSP families to BMEC and BBB function. Although investigators mainly report protective effects of HSPs in brain, contrasted results were obtained in BMEC, which depend both on the HSP and on its location, intra- or extracellular. The therapeutic potential of HSPs must be scrupulously analyzed before targeting them in patients to reduce the progression of brain lesions and improve neurologic outcomes in the long term.-Thuringer, D., Garrido, C. Molecular chaperones in the brain endothelial barrier: neurotoxicity or neuroprotection?
摘要
脑微血管内皮细胞（BMEC）与星形胶质细胞和周细胞相互作用，形成血脑屏障（BBB）。它们功能受损会改变 BBB 的完整性，这与癌症、神经退行性疾病和癫痫发病机制的早期事件有关。有趣的是，这些情况还会诱导热休克蛋白（HSPs）的表达。在这里，我们回顾了主要 HSP 家族对 BMEC 和 BBB 功能的贡献。尽管研究人员主要报告 HSPs 在大脑中的保护作用，但在 BMEC 中得到了相反的结果，这取决于 HSP 及其位置，是细胞内还是细胞外。在针对 HSP 进行治疗之前，必须仔细分析其治疗潜力，以减少脑损伤的进展，并在长期内改善神经功能结局。-图林格，D.，加里多，C. 脑内皮屏障中的分子伴侣：神经毒性还是神经保护？
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