阻断检测：转录驱动的拓扑异构酶 II 在染色质环锚附近发生碰撞，是 DNA 损伤和易位的热点。

Break Check: Transcription-Driven Topoisomerase II Collisions near Chromatin Loop Anchors Are Hotspots for DNA Damage and Translocations.

机构信息

Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, Canada.

Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

出版信息

Mol Cell. 2019 Jul 25;75(2):203-205. doi: 10.1016/j.molcel.2019.07.003.

DOI:10.1016/j.molcel.2019.07.003

PMID:31348877

Abstract

In this issue of Molecular Cell, Gothe, Maman et al. and Canela et al. demonstrate that type II topoisomerase (TOP2B/TOP2A)-mediated DNA breaks, and the oncogenic translocations they generate, are dependent on transcription and governed by chromatin architecture.

摘要

在本期《分子细胞》中，Gothe、Maman 等人和 Canela 等人证明，II 型拓扑异构酶（TOP2B/TOP2A）介导的 DNA 断裂，以及它们产生的致癌易位，依赖于转录，并受染色质结构的控制。