将染色质环锚定到癌症上。

Anchoring Chromatin Loops to Cancer.

作者信息

Fowler Faith, Tyler Jessica K

机构信息

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Pharmacology Graduate Program, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.

出版信息

Dev Cell. 2017 Aug 7;42(3):209-211. doi: 10.1016/j.devcel.2017.07.013.

DOI:10.1016/j.devcel.2017.07.013

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5859922/

Abstract

Although some genomic rearrangements are caused by replication or transcription, the etiology of others is unclear. Reporting in Cell, Canela et al. (2017) reveal that type II topoisomerase-mediated release of torsional strain at chromosomal loop anchors generates DNA double-strand breaks that drive multiple oncogenic translocations in a transcription-independent manner.

摘要

虽然一些基因组重排是由复制或转录引起的，但其他重排的病因尚不清楚。卡内拉等人（2017年）在《细胞》杂志上发表报告称，II型拓扑异构酶介导的染色体环锚处扭转应变的释放会产生DNA双链断裂，从而以不依赖转录的方式驱动多种致癌易位。

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