肥胖：头颈部癌症的新驱动因素。

Obesity: An emerging driver of head and neck cancer.

机构信息

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral And Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China; Hubei Key Laboratory of Industrial Microbiology, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China.

出版信息

Life Sci. 2019 Sep 15;233:116687. doi: 10.1016/j.lfs.2019.116687. Epub 2019 Jul 23.

DOI:10.1016/j.lfs.2019.116687

PMID:31348948

Abstract

Obesity has become pandemic and emerged as one of the most critical global health care problems worldwide since last century. Recent studies have demonstrated that there may be a causal link between obesity and higher risks and mortality of cancers, including prostate, breast, colon, and thyroid cancers, head and neck cancer (HNC). This review focuses on the relationship between obesity and HNC, and the molecular mechanism of abnormal lipid metabolism in HNC. Elucidating the mechanism may open up new possibilities for strategies to reduce risk and mortality of HNC in an increasingly obese population.

摘要

肥胖已成为全球性问题，并在上世纪以来成为全球医疗保健面临的最严峻问题之一。最近的研究表明，肥胖与癌症（包括前列腺癌、乳腺癌、结肠癌和甲状腺癌、头颈部癌症）的更高风险和死亡率之间可能存在因果关系。本综述重点关注肥胖与头颈部癌症之间的关系，以及头颈部癌症中异常脂质代谢的分子机制。阐明该机制可能为在肥胖人群中降低头颈部癌症风险和死亡率的策略开辟新的可能性。