Laboratory of Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, Brasília DF, Brazil.
Service of Clinical Oncology, University Hospital of Brasília (HUB), Brazil.
Photodiagnosis Photodyn Ther. 2019 Sep;27:428-432. doi: 10.1016/j.pdpdt.2019.07.017. Epub 2019 Jul 23.
Basal cell cancer (BCC) is an epithelial neoplasm that arises from basal cells, which constitute the lower layer of the epidermis. Global statistics have shown the progressive increase in the incidence of skin cancer in several countries. The cumulative exposure to solar radiation (ultraviolet B) in the first two decades of life represents the critical risk for the disease. Preclinical and clinical trials have shown photodynamic therapy (PDT) as a promising innovation for treatment of skin cancers, especially to the non-melanoma group. The authors reviewed trials with photodynamic therapy in superficial basal cell carcinoma with different photosensitizers to better evaluate how PDT modifies the natural history of sBCC. We conclude trials should not assess only the immediate efficacy but the main goal of long-term effectiveness of the protocols in order to generate best evidence for clinical practice.
基底细胞癌（BCC）是一种上皮性肿瘤，起源于构成表皮下层的基底细胞。全球统计数据显示，几个国家的皮肤癌发病率呈上升趋势。生命头二十年累积暴露于太阳辐射（紫外线 B）是疾病的关键风险因素。临床前和临床试验表明，光动力疗法（PDT）是治疗皮肤癌，尤其是非黑色素瘤组皮肤癌的一种很有前途的创新疗法。作者回顾了不同光敏剂治疗浅表基底细胞癌的光动力疗法试验，以更好地评估 PDT 如何改变 sBCC 的自然病程。我们得出结论，试验不应仅评估即刻疗效，还应评估方案的长期有效性的主要目标，以便为临床实践提供最佳证据。
