Yadav Prateek Ranjan, Munni Monika Nasrin, Campbell Lauryn, Mostofa Golam, Dobson Lewis, Shittu Morayo, Pattanayek Sudip Kumar, Uddin Md Jasim, Das Diganta Bhusan
Department of Chemical Engineering, Loughborough University, Loughborough LE11 3TU, UK.
Chemical Engineering Department, Indian Institute of Technology, Delhi 110016, India.
Pharmaceutics. 2021 Jul 24;13(8):1132. doi: 10.3390/pharmaceutics13081132.
The ongoing search for biodegradable and biocompatible microneedles (MNs) that are strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical use continues. As such, this review paper is focused upon discussing the key points (e.g., choice polymeric MNs) for the translation of MNs from laboratory to clinical practice. The review reveals that polymers are most appropriately used for dissolvable and swellable MNs due to their wide range of tunable properties and that natural polymers are an ideal material choice as they structurally mimic native cellular environments. It has also been concluded that natural and synthetic polymer combinations are useful as polymers usually lack mechanical strength, stability, or other desired properties for the fabrication and insertion of MNs. This review evaluates fabrication methods and materials choice, disease and health conditions, clinical challenges, and the future of MNs in public healthcare services, focusing on literature from the last decade.
对于可生物降解且生物相容、强度足以穿透皮肤屏障、易于制备并能转化用于临床的微针（MNs）的探索仍在继续。因此，本综述论文着重讨论将微针从实验室转化到临床实践的关键点（例如，聚合物微针的选择）。该综述表明，聚合物因其具有广泛的可调性质而最适合用于可溶解和可膨胀的微针，并且天然聚合物是理想的材料选择，因为它们在结构上模仿天然细胞环境。还得出结论，天然和合成聚合物组合是有用的，因为聚合物通常缺乏制造和插入微针所需的机械强度、稳定性或其他性能。本综述评估了制造方法和材料选择、疾病与健康状况、临床挑战以及微针在公共医疗服务中的未来，重点关注过去十年的文献。
Zotero 插件
