Geriatrics Clinic, Department of Internal Medicine and Medical Specialties (DIMI), University of Genoa, 16132 Genoa, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Int J Mol Sci. 2019 Jul 25;20(15):3647. doi: 10.3390/ijms20153647.
Alzheimer's disease and vascular dementia are estimated to be the most common causes of dementia, although mixed dementia could represent the most prevalent form of dementia in older adults aged more than 80 years. Behavioral disturbances are common in the natural history of dementia. However, so far, there is a paucity of studies that investigated the causal association between behavioral psychological symptoms of dementia and dementia sub-types, due to the high heterogeneity of methodology, study design and type of clinical assessment. To understand the scant evidence on such a relevant clinical issue, it could be hypothesized that a new shifting paradigm could result in a better identification of the relationship between behavioral disturbances and dementia. This narrative review provides an update of evidence on the behavioral patterns associated with different dementia sub-types and offers a potential future perspective as common ground for the development of new translational studies in the field of behavioral disturbances in dementia and the appropriateness of psychoactive treatments.
阿尔茨海默病和血管性痴呆估计是痴呆症最常见的病因，尽管混合性痴呆症在 80 岁以上的老年人中可能代表最常见的痴呆症形式。行为障碍在痴呆症的自然病程中很常见。然而，迄今为止，由于方法学、研究设计和临床评估类型的高度异质性，研究痴呆症的行为心理症状与痴呆症亚型之间因果关系的研究很少。为了了解这一相关临床问题的证据匮乏，我们可以假设一种新的转变范式可能会更好地确定行为障碍与痴呆症之间的关系。本叙述性综述提供了与不同痴呆亚型相关的行为模式的最新证据，并为行为障碍领域的新转化研究以及精神活性治疗的适当性提供了一个潜在的未来视角。
